Immunology

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Author:
ssbhat
ID:
200463
Filename:
Immunology
Updated:
2013-02-13 23:41:29
Tags:
Immunology
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Description:
Cytokines
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  1. TNF
    Source: macrophages, T cells

    Fxns: fever, inflammation (leukocytosis), acute phase reactant, septic shock (hypotension, low CO, low SVR, ARDS
  2. IL-1
    • Source: macrophages, endothelial cell
    • Fxns: fever, inflammation, secrete chemokines, acts on T cells
  3. IL-2
    Source: T cells


    Fxns: T cell proliferation
  4. IL-4
    Source: Th2

    Fxns: Isotype switching (IgE, IgG), B cell growth, Th2 differentiation
  5. IL-5
    Source: Th2

    Fxns: B cell differentiation and growth, isotype switching (IgA), stimulate eosinophils
  6. IFN alpha/beta
    Source: macrophages, DCs, fibroblasts

    Fxns: inhibit viral growth, increase MHC1 expression, stimulate NK cells
  7. IFM gamma
    Source: T cells, NK Cells

    Fxns: Stimulate phagocytosis (activate macrophages)
  8. IL-12
    Source: macrophages, DCs

    Fxn: Act on NK/T cells to increase IFN-gamma, Th1 differentation
  9. IL-10
    Source: Th2 cells, macrophages, DC

    Fxns: Inhibits Th1 response (inhibiting production of IL-12)
  10. IL-6
    Source: T cells, macrophages

    Fxns: Fever, acute phase reactant(liver), stimulates B cells, Th17 differentiation
  11. IL-8
    Source: macrophages

    Fxns: attract neutrophils
  12. IL-15
    source: macrophages

    fxns: NK proliferation (also some neutrophil)
  13. IL-18
    Source: macrophages

    Fxns: IFN-gamma production by NK cells
  14. TGF beta
    Source: Th17

    Function: Th17 differentiation, inhibition of inflammation, isotype switching (IgA)

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