Antifungal Drugs

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  1. Griseofulvin
    • disrupts cell division
    • result: inhibited fungal mitosis (reproduction)
    • older drug; new drugs more commonly used
  2. Flucytosine
    • taken up by fungal cells and interferes with DNA synthesis
    • Result: fungal cell death
  3. Polynes mechanism of action
    • bind to sterols (ergosterol) in cell membrane
    • results in fungal cell death
  4. Imidazoles and triazoles mechanism of action
    • inhibit fungal cell cytochrome P-450 enzymes
    • leads to altered cell membrane and cell death
  5. Echinocandins
    • prevent the synthesis of glucans, needed for the cell wall
    • causes fungal cell death
  6. Amphotericin B Adverse Effects
    • fever, chills, cardiac dysrhythmias, nausea and GI upset, renal toxicity, headache, malaise, hypotension, tingling, numbness in hands and feet, lowered potassium and magnesium levels
    • renal toxicity
    • neurotoxicity: seizures and paresthesias 
  7. Fluconazole Adverse Effects
    • nausea, vomiting, diarrhea, stomach pain
    • increased liver enzymes
  8. Nystatin Adverse Effects
    nausea, vomiting, anorexia, diarrhea, local irritation, rash
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Antifungal Drugs
2013-02-15 03:56:21
Pharm test

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