- High doses can cause hypertension, requiring reduction in infusion rate
Dosage (Adult and Pedi)
- Anaphylaxis: infusion of 20 mcg/kg/min
- Cardiogenic Shock (Pulmonary edema with non-hypovolemic hypotension): Infusion of 10 mcg/kg/min
- Bradycardia: Infusion of 10 mcg/kg/min
- Crush: Infusion of 2 mcg/kg/min
- 400mg in 5 mL of solvent - ampules or vials
- Also supplied as premixed solutions of 400mg in 250mL - concentration of 1600mcg/mL
- Extravasation (infiltration) of dopamine will cause tissue necrosis and sloughing. Notify hospital staff if IV with dopamine infiltrated, as administration of phenotolamine (Regitine) to the area of infiltration is needed to treat infiltration/extravasation.
- Monoamine oxidase inhibitors (MAOI), such as isocarboxazid (Marplan), tranylycpromine sulfate (Paranate), phenelzine sulfate (Nardil) - potemtiate effects of dopamine. Patients receiving these drugs should receive 1/10th the usual dose.
- If infusion rate must be discontinued due to hypertension or tachyarrythmias, taper gradually rather than abruptly terminating the infusion to prevent an acute hypotensive response.