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What are the main histologic components of the dermis?
- Below the epidermis
- Papillary layer- Meissner corpuscle & Kause end bulb
- Reticular layer- Pacinian & Ruffini corpuscle
Compare basal cell & squamous cell carcinoma
- Basal- most common form of skin cancer; pearly in appearance (on face)
- Squamous- sun damaged skin; scaly spots; cancer
What are the main functions of the skin?
covers soft tissue, protection, regulate body temp, sensation from environment, water barrier, 1st line of defense, absorb UV light
raised lesion <1cm
What is scabies?
- Skin disease cause by a mite that lives in the epidermal layer
- Contagious and itchy
any loss of surface coverage
inflammation of the hair follicle
raised lesion >1cm
List ABCDE diagnosis of malignant melanoma
- A- asymmetrical border
- B- border irregularity
- C- color change
- D- diameter change
- E- elevated/ expanding
What is seborrheic keratosis?
- Slightly elevated surface, rough wartlike texture
- Rolls with skin, not anchored
- On face, chest, shoulders, back, etc
- Skin infection of group of hair follicles
- Forms lump deep in skin and contains pus
What is urticaria?
- Itchy rash that appears/ disappears anywhere on the body
- Associated with allergies
What is albinism?
- Hereditary inability of melanocytes to produce melanin
- Increased possibility of skin cancer
pus filled blister
raised red itching lesion
What are the histologic components of th epidermis?
- Stratified squamous keratinized epithelium
- Contains keratinocytes, melanocytes, Lagerhans cells, and Merkel cells
Describe superficial dermatophytosis (fungal infection)
- Ringworm, athlete's foot, jock itch
- Can spread by touching an infected person, damp surfaces, or from a pet
Describe pathology of acne and explain pathogenesis
- Bacterial skin condition that causes pimples (whiteheads, blackheads)
- Tiny pores in surface of skin become clogged
Most important signs of skin cancer?
- Atypical moles/ growth on skin
- Lesions that itch, bleed or don't heal
What is seborrheic dermatitis?
Causes flaky white/yellow scales to form on oily patches of skin around scalp and ear
fluid filled cavity
- Involves hair follicle and nearby skin tissue
Compare freckle with lentigo and nevus
- Freckle- group of melanocytes
- Lentigo- larger group of melanocytes
- Nevus- birthmark/mole
What is ichthyosis?
- Fish scale disease (autoimmune)
- Scaly skin on legs and arms
- Cycling epidermal layer faster than usual
fluid filled blister
- Common bacterial infection of the skin
- Single/many blisters filled with pus
- Increase in number of proliferating cells in stratum basale and stratum spinosum
- Greater epidermal thickness and more rapid renewal of epidermis
malignant tumor of melanocytes
What is eczema?
- Intensely itchy rash that appears as dry skin (autoimmune)
- No cure and not contagious
- Condition runs in families and often occurs with asthma and hay fever
Describe insect bites
- Skin reaction that lasts up to a few days
- Different insects inject different irritants into the skin that cause irritation