Card Set Information
Drug Metabolism and Disposition cards
What is the difference between pharmacokinetics and pharmacodynamics?
Pharmacokinetics: what the body does to the drug
Pharmacodynamics: what the drug does the the body
All processes from the site of administration to the site of measurement
Reversible transfer of substance between site of measurement and other sites within the body
Irreversible loss of unchanged substance by chemical conversion
Irreversible loss of unchanged substance from the site of measurement
Irreversible loss of unchanged substance from the body
Elimination and distribution
Pharmacokinetic behaviour is a function of...
Physicochemical and structural properties of a drug
Route of administration
Physiology/anatomy of the body
Pharmacokinetics is influenced by...
Name the four types of metabolism a drug can undergo and state which phase of reactions it belongs to
Which three functional groups do we need to be concerned with?
Which is the main phase I reaction
Where does oxidation occur?
C hydroxylations: aromatic or aliphatic Cs
C cleavage: loss of alkyl, amino etc
N or S oxidations
Where does reduction act?
Nitro and keto groups
Where does hydrolysis act?
Ester and amide groups
Phase II reactions and their functional groups
Glucuronidation -OH -CO2H -NH2
Glycine conjugation - CO2H