drugmetabolism

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Author:
laurajane.price
ID:
20224
Filename:
drugmetabolism
Updated:
2010-05-21 18:28:11
Tags:
drug metabolism
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Description:
Drug Metabolism and Disposition cards
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  1. What is the difference between pharmacokinetics and pharmacodynamics?
    Pharmacokinetics: what the body does to the drug

    Pharmacodynamics: what the drug does the the body
  2. Define ADME
    • Absorption
    • Distribution
    • Metabolism
    • Elimination
  3. Define absorption
    All processes from the site of administration to the site of measurement
  4. Define distribution
    Reversible transfer of substance between site of measurement and other sites within the body
  5. Define metabolism
    Irreversible loss of unchanged substance by chemical conversion
  6. Define elimination
    Irreversible loss of unchanged substance from the site of measurement
  7. Define excretion
    Irreversible loss of unchanged substance from the body
  8. Define disposition
    Elimination and distribution
  9. Pharmacokinetic behaviour is a function of...
    Physicochemical and structural properties of a drug

    Dosage form

    Route of administration

    Physiology/anatomy of the body
  10. Pharmacokinetics is influenced by...
    Genetics

    Size

    Age

    Disease

    Other drugs

    Environmental factors
  11. Name the four types of metabolism a drug can undergo and state which phase of reactions it belongs to
    Phase I:

    Oxidation

    Reduction

    Hydrolysis

    Phase II:

    Conjugation
  12. Which three functional groups do we need to be concerned with?
    OH

    CO2H

    NH2
  13. Which is the main phase I reaction
    Oxidation
  14. Where does oxidation occur?
    C hydroxylations: aromatic or aliphatic Cs

    C cleavage: loss of alkyl, amino etc

    N or S oxidations
  15. Where does reduction act?
    Nitro and keto groups
  16. Where does hydrolysis act?
    Ester and amide groups
  17. Phase II reactions and their functional groups
    Glucuronidation -OH -CO2H -NH2

    Sulphation -OH

    Glycine conjugation - CO2H

    Acetylation -NH2

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