clin med test 4

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lakelley88
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202365
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clin med test 4
Updated:
2013-02-21 17:00:57
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clin med test
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clin med test
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  1. S/S of Duchenne
    • clumsy gait
    • lordotic posture
    • calf hypertrophy
  2. dystrophinopahties have def. in
    dystrophin protein

    anchors F-actin to plasma membrane of muscle
  3. Duchenne kids die by age?
    from what?
    • 25
    • from respiratory problems
  4. Duchenne have elevated
    CK
  5. Becker muscular dystrophy
    • muscle cramps
    • calf hypertorphy
    • exercise intolerance
    • quad myopathy 
    • calf pain

    cardiomyopahty
  6. condition when absence of Telethonin
    limb-girdle muscular dystrophy
  7. s/s of limb-girdle
    • distal m weakness
    • weakness of shoulders,
  8. mc type of myotonic dystrophy
    adult muscular dystrophy
  9. s/s of adult muscular dystrophy
    • pstosis, atrophy of masseter/temporal m
    • narrow facial structure
    • myotonia-slow relaxation of muscles
    • apathy, poor contration
    • cardiac/pulmonary problems
  10. diagnosis of adult muscular dystrophy
    EMG
  11. s/s of facioscapulohumeral muscular dystrophy
    • face weakness
    • scapular weakness
    • food drop, ant. tibial muscle weakness
  12. causes of malignant hypertension (5)
    • halothane
    • enflurane
    • desflurane
    • cycleopropane
    • ether
    • succinylcholine
  13. s/s of malignant hyperthermia
    • temp >109F
    • m. twitching
    • clenching of m. 
    • runs in family
  14. tx of malig. hyperthermia
    dantrolene
  15. myasthenia gravis s/s
    • ptosis, diplopia, 
    • symptoms get worse the more you use the muscle
  16. myasthenia gravis a problem with
    ACH receptors. autoimmune against the receptors, not as many, and so muscles can't move as fast
  17. dx of myasthenia gravis confirmed by
    • acetylchonine esterase inhibiter test
    • -edrophonium or neostigmine

    or repetitive n. stimulation tests
  18. treatment of myasthenia gravis
    • anticholinesterase
    • tymectomy
    • prednisone-first line immunotherapeutic drug
  19. lambert-eaton myasthenic syndrome s/s
    • gets better with use 
    • assoc w SCLC

    • proximal m weakenss
    • hyporeflexia
  20. s/s of Lour Gehrig disease or amyotrophic lateral sclerosis
    • progressive weakness and paralysis 
    • death from 2-5 years after onset 

    loss of motor neurons

    • upper motor problems
    • --clonus hyperreflexia

    • lower motor problems
    • --atrophy, weakness, fasciculations
  21. dx of Lour Ghrig disease
    • EMG studies  
    • denervation in 3 extremities
  22. tx with Lou Gehrig
    • treat symptoms 
    • need ventilator 

    riluzole prolongs life by 4 months

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