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lakelley88
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S/S of Duchenne
- clumsy gait
- lordotic posture
- calf hypertrophy
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dystrophinopahties have def. in
dystrophin protein
anchors F-actin to plasma membrane of muscle
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Duchenne kids die by age?
from what?
- 25
- from respiratory problems
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Duchenne have elevated
CK
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Becker muscular dystrophy
- muscle cramps
- calf hypertorphy
- exercise intolerance
- quad myopathy
- calf pain
cardiomyopahty
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condition when absence of Telethonin
limb-girdle muscular dystrophy
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s/s of limb-girdle
- distal m weakness
- weakness of shoulders,
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mc type of myotonic dystrophy
adult muscular dystrophy
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s/s of adult muscular dystrophy
- pstosis, atrophy of masseter/temporal m
- narrow facial structure
- myotonia-slow relaxation of muscles
- apathy, poor contration
- cardiac/pulmonary problems
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diagnosis of adult muscular dystrophy
EMG
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s/s of facioscapulohumeral muscular dystrophy
- face weakness
- scapular weakness
- food drop, ant. tibial muscle weakness
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causes of malignant hypertension (5)
- halothane
- enflurane
- desflurane
- cycleopropane
- ether
- succinylcholine
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s/s of malignant hyperthermia
- temp >109F
- m. twitching
- clenching of m.
- runs in family
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tx of malig. hyperthermia
dantrolene
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myasthenia gravis s/s
- ptosis, diplopia,
- symptoms get worse the more you use the muscle
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myasthenia gravis a problem with
ACH receptors. autoimmune against the receptors, not as many, and so muscles can't move as fast
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dx of myasthenia gravis confirmed by
- acetylchonine esterase inhibiter test
- -edrophonium or neostigmine
or repetitive n. stimulation tests
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treatment of myasthenia gravis
- anticholinesterase
- tymectomy
- prednisone-first line immunotherapeutic drug
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lambert-eaton myasthenic syndrome s/s
- gets better with use
- assoc w SCLC
- proximal m weakenss
- hyporeflexia
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s/s of Lour Gehrig disease or amyotrophic lateral sclerosis
- progressive weakness and paralysis
- death from 2-5 years after onset
loss of motor neurons
- upper motor problems
- --clonus hyperreflexia
- lower motor problems
- --atrophy, weakness, fasciculations
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dx of Lour Ghrig disease
- EMG studies
- denervation in 3 extremities
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tx with Lou Gehrig
- treat symptoms
- need ventilator
riluzole prolongs life by 4 months
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