Mouse Strains

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Author:
vet1999
ID:
20240
Filename:
Mouse Strains
Updated:
2011-03-10 17:07:31
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ACLAM mouse mice strains stocks inbred outbred
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Mouse Strains
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  1. SJL
    • - Susceptible to autoimmune induced encephalitis
    • (multiple sclerosis)

    - Retinal degeneration

    - High incidence of reticulum cell sarcomas

    - Males extremely aggressive

    - Susceptible to LDV

    - Resistant to ectromelia
  2. WAG/RIJ
    retinitis pigmentosa
  3. NZB & F1 of NZBxNZW
    - Autoimmune diseases similar to human SLE

    - Resistant to diet induced atherosclerosis
  4. SWR/J
    • Sendai virus
    • Resistent to Salmonella enteritidis
  5. SWR
    TMEV
  6. scid
    • Chromosome 16
    • Lack T and B cells
    • Thymis lymphoma (more in irradiated)
  7. Swiss Webster
    typhlocolitis
  8. Swiss Albino
    mycobacterium
  9. Swiss
    • MEMV
    • K virus suckling mice
    • Retinal degeneration
    • Resistent to Citrobacter rodentium
  10. xid
    • Lacks B cells
    • Bruton’s tyrosine
    • kinase gene affecting signal transduction in B cells
    • ↓ B cell #, low IgM, impaired response to polysaccharide antigens
    • Human X-linked agammaglobulinemia
  11. FVB/N
    - "Follicle very big"

    - Most frequently used mouse to superovulate for transgenic egg retrieval

    - Retinal degeneration
  12. DBA
    - Model for rheumatoid arthritis

    - High incidence of mammary tumors

    - Susceptible to audiogenic seizure

    - Dystrophic mineralization of cardiac & skeletal muscle

    - Extreme intolerance to morphine and alcohol
  13. C3H/St
    Resistent to Salmonella enteritidis
  14. C3H/HeN
    • Mycoplasma pulmonis
    • Resistent to M. avium
    • Resistent to Salmonella enteritidis
    • Preputial gland abscess (Staph. aureus)
    • Lyme Dz
  15. C3H/HeJ
    • M. avium intracellulare more severe lesions than C3H/HeB/FeJ (LPS unresponsive)
    • Selmonella enteritidis
  16. C3H/HeB/FeJ
    M. avium intracellulare (LPS responsive)
  17. C3H/He
    • Giardia muris
    • Low incidence of Murine leukemia virus
    • Resistent to Salmonella typhimurium
  18. C3H/Fa
    Murine leukemia virus
  19. C3H/Bi
    Resistent to Salmonella enteritidis
  20. CBA(CB)
    • - Retinal degeneration
    • - Exocrine pancreatic insufficiency
    • - Model for granulomatous autoimmune thyroiditis
  21. C3H
    • Retinal degeneration (Pde6brd1), blindness by weaning age
    • Alopecia areata
    • High incidence of mammary tumors
    • High incidence of dystrophic mineralization
    • High incidence of hepatomas in males
    • Susceptible to Ectromelia
    • Citrobacter rodentium
    • MMTV
    • K virus
    • Resistant to amyloidosis
    • Resistent to MHV
    • Skeletal muscle mineralization
    • Hepatacellular carcinoma with mets
  22. Beige Mouse
    bg/bg
    • Chromosome 13
    • NK impared
    • Elevated bleeding tendencies
  23. BC3F1
    • Cystic endometrial hyperplasia
    • Fibrous replacement of bone marrow with estrogen replacement
  24. BALB/cByJ
    Reye's syndrome
  25. BALB/c
    • -Production of monoclonal antibodies
    • -Sensitive to radiation
    • -Hypocallosity
    • -Low incidence of mammary tumors
    • - High incidence of dystrophic mineralization
    • - Susceptible to Ectromelia
    • Sendai virus
    • MHV
    • Salmonella typhimurium
    • Salmonella enteritidis
    • Helicobacter hepaticus: Typhlocolitis
    • - Resistant to amyloidosis

    • Resistent to mousepox
    • Resistent to giardia muris
    • Resistent to E. cuniculi
    • Resistent to hepatic carcinogenisis
    • -Reye’s like syndrome
    • Fatty liver
  26. BALB
    • Bronchioalveolar adenoma
    • Myoepitheliomas
    • Pregnancy toxemia
    • Epicacrdial mineralization
    • size of RE system
    • Glomerular hylinosis (aged)
  27. AKR
    • Murine leukemia virus
    • LDEV select virus isolates
    • E. cuniculi
    • Resistent to mousepox
    • Glomerular hylinosis
    • Thymic lymphoma
    • Low incidence of mammary tumors
  28. A/JCr
    Helicobacter hepaticus
  29. A/J
    • Interemediate suspectibility Sendai virus
    • Giardia muris
    • Helicobacter hepaticus: typhlocolitis
    • Resistent Salmonella enteritisdis
    • Low incidence Murine leukemia virus
    • Pulmonary adenoma
    • Lung carcinogenisis
  30. A/HeN
    Resistent to Selmonella enteritidis
  31. A/HeJ
    Intermediate susceptibility Sendai virus
  32. A
    • Ectromelia
    • K virus lethal to suckling mice
    • MCMV
    • MMTV
    • Resistent to TMEV
    • Resistent to Salmonella enteritidis
    • Mast cells in spleen
    • Mammary carcinoma
    • Primary amyloidosis
    • Bronchialveolar adenoma
  33. 129/ReJ
    Sendai virus
  34. 129/J
    • Sendai virus
    • Encephalitozoon cuniculi
    • Cornebacterium
    • Vulvar squamous cell carcinoma3
    • Most frequent source for embryonic cells
    • Testicular teratomas are common
    • Hypocallosity is relatively common
    • Prone to mega esophagus and epithelial hyalonosis
  35. 129
    • KO stem cells
    • teratomas
  36. C57BL (B)
    • - High incidence of micropthalmia, hydrocephalus,
    • dermatitis

    - Preference for alcohol and sweet tastes

    - Reticulum cell sarcomas are common in old mice

    - Resistant to ectromelia

    - Resistant to irradiation
  37. Nude
    • T-cell deficient C’some 11
    • Transcription factor controlling thymic epithelial cell differentiation
    • Athymic/hairless (unrelated but linked)
    • Tumor & xenograft studies
  38. SCID
    • T & B- cell deficient C’some 16
    • DNA-dependent kinase, recombines gene segments coding for T (TcR) & B (Ig) cell receptors
    • No T cell fxns, hypoplastic lymphoid tissues, No Ig /T cell responses, sensitive to ionizing radiation (defective DNA break repair)
    • V(D)J recombination studies, Tumor & xenograft transplantation, lymph subset transfer, reconstitution of human hematopoietic system (Hu-PBL-SCID)
  39. Rag-1

    & Rag-2
    • T & B cell deficient
    • C’some 2p
    • Recombinase enzymes, prevents formation of functional B α (Ig) & T (TcR) cell receptors
    • Hypoplastic lymphoid tissues, no Ig or T cell
    • responses
    • V(D)J recombination studies, Tumor & xenograft transplantation, lymph subset transfer
  40. Moth-eaten
    • Lack T & NK cells
    • Recessive mutation C’some 6
    • Phosphatase, impaired signal transduction from cell receptors
    • Def humoral/cellular immunity, lack cytotoxic T & NK cells, moth-eaten pelage 2⁰ to folliculitis, autoimmune syndromes, hypergammaglobulinemia
    • Apoptosis studies, Autoimmune syndromes
  41. Beige
    • NK cell deficient
    • C’some 13
    • Mutation on c’some 13, affects pigment granules (coat, retina), & lysosomal granules of type II pneumocytes, mast cells, & NK cells
    • Diluted coat color, lysosomal storage DZ, impaired chemotaxis, bactericidal activity of neuts, ↓NK activity
    • Chediak-Higashi syndrome, crossed onto nude or SCID for multiple immune defs
  42. 1 pr & gld
    • Impaired apoptosis from Fas (1 pr) or Fas ligand (gld) defect
    • Generalized lymphoproliferative DZ (gld), autoimmunity, immunodeficiency
    • Apoptosis studies, Autoimmune syndromes
  43. Cytokine

    KO (IL-2, IL-10, IFN-γ, TNF-β, others)
    • Genetically engineered disruption of cytokine
    • Anemia (IL-2), wasting (IL-2, IL-10), & IBD (IL-2 & IL-10) when housed conventionally
    • Physiological role of cytokines in immune response & inflammation
  44. Receptor KO (TcR, Ig, cytokine, MHC, adhesion molecules, integrins)
    • Genetically engineered disruption of receptor gene
    • Lack functional response to signal of interest, variable immune compromise, IBD common in TcR
    • KO
    • Physiological role of receptors in immune response & inflammation

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