The angine drug _______ is typically administered for ______ because of the first pass effect.
The angine drug nitroglycerin is converted in the active vasodilator molecule ______ by reaction with the amino acid cysteine.
A drug family that is also used to tx angina:
calcium channel blockers
Use of angina drugs has dropped in the last decade due to increased use of ______.
A drug for CHF that causes a positive inotropic effect:
A common The ionic polysacchride anticoagulant that is administered IV:
Nitroglycerin reduces angina by causing primarily (venous/arterial) vasodilation.
Another dug besides nitroglycerin that is metabolized into the active molecule nitric acid:
Two drug families besides organic nitrates that are used to stop angina attacks:
Beta 1 blockers
Calcium channel blockers
Anticoagulant the blocks vitamin K synthesis:
Anticoagulant that must be given by injection:
Anticoagulant that is teratogenic:
A partially purified anticoagulant whose clotting times are reproducible:
Oral anticoagulants measure their clotting times with a 3 letter abbrev. ___ which stand for _______
International normalized ratio
If the INR of an anticoagulant is 1, the pt is at a higher risk of (bleeding/clotting/neither).
Names of 2 most commonly RX drugs in the "blockbuster" family that inhibits cholesterol synthesis:
Statin drugs occasionally cause damage to two organs/tissue in the body:
A drug which reduces serum triglycerides (as well as LDL) _______. This drug doesn't reduce the risk of MI/stroke. The lowering of lipids in this case is a _______ outcome which does not produce the desired ______ outcome.
A drug which lowers absorption dietary cholesterol:
Zetia is commonly combined with a stain drug and sold as:
An anticoagulant from pig intestines that is given by injection:
An injection anticoagulant with more reproducible activity than heparin:
An anticoagulant with a very short half life:
The activity of the anticoagulant ________ is measured with an ___ number.
A patient with an INR = 1.2 is at the risk of having (hemorrhage/heart attack).
Drug used to inhibit platelet aggregation:
A naturally ocurring enzyme which dissolves clots:
The most commonly RX generic statin:
Best selling statin drug still under patent:
A drug which inhibits the absorption of dietary cholesterol:
Sales of ____ dropped after a trial which showed that it did not reduce the risk of MI and stroke.
A vitamin which lowers cholesterol when taken in megadoses:
Large doses of NSAIDs may cause ______ of renal a.
NSAIDs are also often used to tx menstrual cramps, medically referred to as:
An OTC NSAID that advertises is lasts the "whole day":
A person with a total/HDL ratio of 10 is at ___ risk of MI and ischemic stroke
A person with a total/HDL ratio of 4 is at _____ risk of MI and ischemic stroke
NSAIDs work at a molecular level by inhibiting the enzyme COX which stand for _______. This enzyme synthesizes the inflammatory molecules:
Celecoxib (Celebrex) claimed to only inhibit the isozyme:
Cox - 2
The most common adverse effect of NSAIDs is:
The potent rx NSAID that should not be used for more than 5 days:
Common OTC NSAID with a 6-8 hour half life:
Major advantage of tylenol over other NSAIDs:
Doesn't cause gastric ulcers
A drug that is rx for RA as well as cancer:
An injectable drug that is inhibits tumor necrosis factor that is used for a variety of auto-immune disease: