Pharm - Quiz 6

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Author:
jared.seehawer
ID:
202404
Filename:
Pharm - Quiz 6
Updated:
2013-02-21 20:16:31
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chem360 pharmacology
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Description:
NSAIDs and CVS
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  1. The angine drug _______ is typically administered for ______ because of the first pass effect.
    • nitroglycerin
    • sublingually
  2. The angine drug nitroglycerin is converted in the active vasodilator molecule ______ by reaction with the amino acid cysteine.
    nitric oxide
  3. A drug family that is also used to tx angina:
    calcium channel blockers
  4. Use of angina drugs has dropped in the last decade due to increased use of ______.
    angioplasty/stente
  5. A drug for CHF that causes a positive inotropic effect:
    digoxin
  6. A common The ionic polysacchride anticoagulant that is administered IV:
    heparin
  7. Nitroglycerin reduces angina by causing primarily (venous/arterial) vasodilation.
    venous
  8. Another dug besides nitroglycerin that is metabolized into the active molecule nitric acid:
    dinitrate
  9. Two drug families besides organic nitrates that are used to stop angina attacks:
    • Beta 1 blockers
    • Calcium channel blockers
  10. Anticoagulant the blocks vitamin K synthesis:
    Warfarin (Coumadin)
  11. Anticoagulant that must be given by injection:
    heparin
  12. Anticoagulant that is teratogenic:
    warfarin (Coumadin)
  13. A partially purified anticoagulant whose clotting times are reproducible:
    enoxaparin
  14. Oral anticoagulants measure their clotting times with a 3 letter abbrev. ___ which stand for _______
    • INR
    • International normalized ratio
  15. If the INR of an anticoagulant is 1, the pt is at a higher risk of (bleeding/clotting/neither).
    Neither
  16. Names of 2 most commonly RX drugs in the "blockbuster" family that inhibits cholesterol synthesis:
    • simvastatin
    • atorvastatin
  17. Statin drugs occasionally cause damage to two organs/tissue in the body:
    • liver
    • muscle
  18. A drug which reduces serum triglycerides (as well as LDL) _______. This drug doesn't reduce the risk of MI/stroke. The lowering of lipids in this case is a _______ outcome which does not produce the desired ______ outcome.
    • fenofibrate (Tricor)
    • surrogate
    • clinical
  19. A drug which lowers absorption dietary cholesterol:
    Zetia
  20. Zetia is commonly combined with a stain drug and sold as:
    Vytorin
  21. An anticoagulant from pig intestines that is given by injection:
    heparin
  22. An injection anticoagulant with more reproducible activity than heparin:
    enoxaparin (Lovenox)
  23. An anticoagulant with a very short half life:
    heparin
  24. The activity of the anticoagulant ________ is measured with an ___ number.
    • warfarin
    • INR
  25. A patient with an INR = 1.2 is at the risk of having (hemorrhage/heart attack).
    Heart attack
  26. Drug used to inhibit platelet aggregation:
    Plavix
  27. A naturally ocurring enzyme which dissolves clots:
    plasmin
  28. The most commonly RX generic statin:
    simvastatin
  29. Best selling statin drug still under patent:
    atorvastatin (Lipitor)
  30. A drug which inhibits the absorption of dietary cholesterol:
    Zetia
  31. Sales of ____ dropped after a trial which showed that it did not reduce the risk of MI and stroke.
    Zetia
  32. A vitamin which lowers cholesterol when taken in megadoses:
    niacin
  33. Large doses of NSAIDs may cause ______ of renal a.
    vasoconstriciton
  34. NSAIDs are also often used to tx menstrual cramps, medically referred to as:
    dysmenorrhea
  35. An OTC NSAID that advertises is lasts the "whole day":
    naproxen
  36. A person with a total/HDL ratio of 10 is at ___ risk of MI and ischemic stroke
    high
  37. A person with a total/HDL ratio of 4 is at _____ risk of MI and ischemic stroke
    average
  38. NSAIDs work at a molecular level by inhibiting the enzyme COX which stand for _______. This enzyme synthesizes the inflammatory molecules:
    • cyclooxygenase
    • prostaglandins
  39. Celecoxib (Celebrex) claimed to only inhibit the isozyme:
    Cox - 2
  40. The most common adverse effect of NSAIDs is:
    • MI
    • Stroke
  41. The potent rx NSAID that should not be used for more than 5 days:
    keto'rolac
  42. Common OTC NSAID with a 6-8 hour half life:
    naproxen
  43. Major advantage of tylenol over other NSAIDs:
    Doesn't cause gastric ulcers
  44. A drug that is rx for RA as well as cancer:
    methotrexate
  45. An injectable drug that is inhibits tumor necrosis factor that is used for a variety of auto-immune disease:
    Humira

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