Adrenergic Drugs

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Adrenergic Drugs
2013-02-22 09:47:02

Ch. 18 SNS and Adrenergic Drugs. Test 2
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  1. What is another name for an adrenergic drug?
    Sympathomimetic drug
  2. What is salmeterol (Serevent) used for?
    inhaler used for prevention of asthma attack; not for an acute attack.
  3. how does phenylephrine drops help with nasal decongestion?
    vasoconstriction in the nasal mucosa. this produces shrinkage of the mucosa and promotes either nasal breathing.
  4. why is albuterol given via inhalation?
    inhaled albuterol works almost immediatly.
  5. drugs that stimulate and mimicĀ  the actions of the sympathetic NS?
    adrenergic drugs
  6. adrenergic receptor located on presynaptic nerve terminals.
    alpha 1
  7. adrenergic receptors located on post synaptic effector cellsĀ such as tissue, muscle, or organ that the nerve stimulates.
    alpha 1
  8. adrenergic receptor located primarily in the heart?
    beta 1
  9. adrenergic receptor located in smooth muscle fibers of bronchioles, arterioles, and visceral organs.
    beta 2
  10. the predominant alpha agonist response is..
    vasoconstriction and cns stimulation
  11. SNS neurotransmitters, also known as catecholamines and sympathomimetics
    • norepinephrine
    • epinephrine
    • dopamine
  12. beta adrenergic response results in
    bronchial, GI, and uterine smooth muscle relaxation, glycogenolysis, and cardiac stimulation.
  13. alpha adrenergics are _____ and their blockers are______
    constricters; dilaters.
  14. beta adrenergics are_____ and their blockers are______
    dilaters; constricters
  15. catecholamines are specifically metabolized by which two specific enzymes?
    monoamine oxidase (MOA), catechol ortho-methultransferase (COMT)
  16. where does MOA break down catecholamines?
    nerve endings
  17. where does COMT break down catecholamines?
    outside nerve ending at the synaptic cleft
  18. Binds directly to the adrenergic receptor and causes a physiologic response.
    • direct-acting
    • ex:epinephrine
  19. adrenergic drug that, when given, causes the release of the catecholamine from the storage site in the nerve ending; it then binds to the effector and causes a phsiologic response.
    indirect-acting sympathomimetic
  20. when beta 1 receptors are stimulated by an adrenergic drug, thre things result:
    • 1.positive inotropic effect (increase in force of contraction)
    • 2.positive chronotropic effect (increase in HR)
    • 3.positive dromotropic (increase in conduction of cardiac electrical nerve impulses)
  21. activation of beta 2 receptors produces?
    bronchodilation (relaxation), uterine relaxation, and increased glycogenolysis (glucose release from liver)
  22. dopamine
    Intropin, Beta 1 agonist, inc. BP and cardiac output, contraindicated in patients with pheochromocytoma
  23. midodrine
    Pro-Amatine, Alpha 1 agonist, dont take with psychotics
  24. epinephrine
    Adrenalin, Alpha/Beta agonist, treatment of anaphylaxis, contraindicated in narrow-angle glaucoma *low dose: B1, high dose: Alpha
  25. adrenergics that primarily have cardioselective effects are referred to as..
    vasoactive adrenergics
  26. general side effects of adrenergics
    Inc. HR, BP, dilate pupils, brady/tachycardia, arrythmias, sweat, restless, irritable, nausea
  27. general indications of adrenergics
    Inc. BP, treatment of hypotension, shock, inc. cardiac output, beta 2 is good for respiratory disease