PCM II

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Author:
islandgirljane
ID:
202654
Filename:
PCM II
Updated:
2013-03-03 00:51:35
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CV packet
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Description:
Cardiovascular drugs
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  1. What is the generic name for Aldomet? dosage strength? indications?
    • -Methlydopa
    • -125, 250, 500mg 
    • -intial 250 mg BID - TID
    • -HTN also for pregnancy
  2. Aldomet (Methyldopa) MOA?
    -central alpha 2 agonist, decreases NE
  3. What is the other medication for HTN in pregnancy?
    Hydralazine
  4. Coumadin (Warfarin) match color to strength
    1mg
    2mg
    2.5mg
    3mg
    4mg
    • pink
    • lavender
    • green
    • brown
    • blue
  5. Coumadin (Warfarin) match color to strength
    5mg
    6mg
    7.5mg
    10mg
    • peach
    • teal
    • yellow
    • white
  6. What is the generic name for Pradaxa? dosage strength? indications?
    • Dabigatran
    • 75 mg & 150 mg BID
    • afib, stroke prophylaxis
  7. Pradaxa (Dabigatran) MOA & impt notes
    • direct thrombin inhibitor
    • BEER's list >75 yrs
    • CrCl >30mL/min 150 mg BID
    • CrCl < 30mL/min 75 mg BID w/ or w/out food
    • routine INR not required
  8. Nitroglycerin SL tabs?
    0.3, 0.4, 0.6 mg
  9. Nitro-Dur Patches ?
    0.1, 0.2, 0.3, 0.4, 0.6, 0.8 mg/hr
  10. Nitrolingual Pump spray?
    • 0.4 mg/metered dose:
    • 200 sprays or 60 sprays
    • DO NOT SHAKE
  11. Nitro-Bid ointment? strength? important points
    • 2% 0.5 to 2 inches applied in AM and 6hrs later
    • 10-12 hr nitrate free perion
    • can be used Q8hrs
  12. Mechanism of Action of NTG products?
    relaxation of vascular smooth muscle via stimulation of intracellular cGMP
  13. NTG Side effect?
    milligram/grain equivalent?
    Counseling point?
    storage?
    • most common is HA
    • 0.4 mg = 1/150gr
    • If, after first SL dose, no improvement or worsening, call 911
    • original glass container
  14. What is the active long-acting metabolite of Isosorbide Dinitrat?
    Isosorbide Mononitrate
  15. Imdur dosage strengths?
    How long does it last?
    Counseling?
    • 30, 60, 120 mg ER 
    • 12 hours
    • Daily HAs marker of drug activity
    • APAP relieves nitrate HA w/low risk
  16. Bidil (Isosorbid dinitrate & hydralazine) special indication?
    dosage?
    • Heart failure as an adjunct in self-indentified black patients
    • 20 mg ISDN & 37.5 mg hydralazine, 1-2 TID
  17. Ranexa generic name?
    how supplied?
    indication?
    important notes
    • Ranolazine ER
    • 500 mg BID (up to 1000 mg BID)
    • Anti-anginal
    • metabolized by CYP-450 & WILL NOT abate an acute angina episode, may cause dizziness
  18. Persantine generic name?
    How supplied?
    indication?
    important notes?
    • Dipyridamole
    • 25, 50, 75 mg
    • adjunct to coumarin type anticoagulants to inhibit platelet aggregation
    • orthostasis, GI upset
  19. Aggrenox capsules
    How supplied?
    Indication?
    • 200 mg ER dipyridamole with 25 mg aspirin
    • stroke, stroke prophylaxis, TIA
  20. How should Aggrenox be dosed?
    What is required for absorption?
    What acid is included in the formulation to improve absorption?
    Improved antithrombotic action b/c?
    Know this drug, commonly used
    • 1 cap BID, morning and evening w/or w/out food
    • pH<4
    • tartaric acid
    • additive antiplatelet effects of both drugs
  21. K-Dur, Klor-Con ER, K-tabs & Micro-K, what dosage strengths are available?
    10mEq (750 mg), 20mEq (1500 mg) 15mEq
  22. What can be substituted if pt cannot swallow K-Dur or put it in water?
    Klor-Con ER is smaller
  23. KCl 8 mEq
    name?
    How supplied?
    notes?
    • Klor-Con
    • 600 mg
    • swallow only
  24. KCl 25 mEq effervescent tabs
    name?
    How used?
    How supplied?
    • K-Lyte/Cl
    • place in water and drink 
    • 10% (20 mEq/15ml) and 20% (40 mEq/15mL)
  25. IV potassium should NEVER BE GIVEN as a?
    bolus
  26. T/F K-Dur can be mixed in water to drink?
    True
  27. Name the loop diuretics
    • Lasix (furosemide)
    • Bumex (Bumetanide)
    • Demadex (Torsemide) 
    • Edecrin (ethacrynic acid)
  28. Where do loops work?
    MOA?
    SE?
    • Ascending loop
    • to inhibit Na/K/2Cl cotransport, Na, Cl, & water retained in tubule; loss of Na, K, Mg, & Ca
    • ototoxicity
  29. What loop can be used if pt has sulfa allergy?
    Edecrin (ethacrynic acid)
  30. Recall the strength conversions for loops
    • Lasix 40 mg = Bumex 1 mg
    • Lasix 40 mg = Demadex 20 mg
  31. T/F Loops have a ceiling? ie. higher dose no increase in water removal
    False. Loops have no ceiling but thiazides do.
  32. Where do thiazides work?
    MOA
    How supplied?
    What mineral/s are loss?
    What mineral/s retained?
    • DCT
    • inhibits reabsorption of Na & Cl, :. water retained in tubule
    • 12.5, 25, 50 mg, also Microzide caps (12.5 mg)
    • Na, K, Mg
    • Ca
  33. Name the thiazide type products and doses
    • Lozol (indapamide) 1.25 & 2.5 mg QD
    • Hygroton (Chlorthalidone) 25, 50, 100 mg QD longest acting
    • Zaroxolyn (Metolazone) 2.5, 5, 10 mg can be used in renally impaired w/ loops
  34. What is Dyazide?
    • Triamterene plus HCTZ
    • 37.5-25 mg
    • also Maxzide same as above and Maxzide 75-50 mg
  35. Aldactone (Spironolactone)
    HTN dose?
    Ascites in cirrhosis dose?
    SE?

    K sparing diuretic
    • HTN 25 mg BID
    • Ascites in cirrhosis 25-50 mg or even higher QID
    • gynecomastia
  36. Inspra (Eplerenone) 
    Tabs?
    Caution?
    • Tabs 25, 50 mg QD or BID
    • hyperkalemia, CYP-450 3A4 products
  37. What is the BBW for Beta Blockers?
    Avoid abrupt D/C. risk of angina and MI.
  38. Non-selective BBlockers
    MOA
    • Inderal (propranolol)
    • Corgard (Nadolol)
    • Visken (Pindolol) with ISA
    • Coreg (Carvedilol)
    • reduce cardiac output, negative ionotrope and negative chronotrope
  39. Inderal (propranolol)
    tabs?
    caps?
    Impt notes for DM
    Impt nots for asthma
    T/F hydrophilic
    • tabs 10, 20, 40, 60, 80 mg
    • caps 60, 80, 120, 160 mg
    • may mask signs and symptoms of hyperglycemia
    • blocks B2 in lungs
    • False. most lipophilic
  40. Inderal (propranolol) recall PK parameters
    only 1 out of a 40 mg PO left in circulation (i.e. 1mg IV is equal to 40 mg PO)
  41. Corgard (nadolol) 
    tabs?
    impt notes
    • tabs 20, 40, 80, 120, 160 mg QD
    • long acting, renally eliminated
  42. Visken Pindolol
    tabs?
    impt notes
    • tabs 5, 10 mg BID
    • partial BBlocker, inhibit EPI & NE yet has some stimulating beta effect
    • less bradycardia

    similar to acebutolol (Sectral) B-1 selective
  43. Selective BBlockers
    • Bystolic (Nebivolol)
    • Lopressor (Metoprolol)
    • Tenormin (Atenolol)
  44. Bystolic (Nebivolol)
    tabs? 
    T/F decreases NO production resulting in vasodilation
    Bi = 2 stolic =systolic?
    • tabs 2.5, 5, 10 mg/day
    • False. Increases NO product/ resulting in vasodilation
    • 2 ways to lower systolic BP
  45. Lopressor (Metoprolol tartrate)
    tabs?
    tabs 50, 100 (brand) also 25 mg generic, QD or BID
  46. Toprol XL (Metoprolol succinate)
    tabs?
    tabs 25, 50, 100, 200 mg QD or BID
  47. Tenormin (Atenolol)
    tabs?
    • tabs 25, 50, 100 mg, inj
    • most hydrophilic
  48. Coreg (Carvedilol)
    tabs?
    caps?
    counseling?
    • tabs 3.125, 6.25, 12.5, 25 mg BID 
    • caps 10, 20, 40, 80mg QAM
    • take w/food to slow absorption & avoid orthostasis
  49. Coreg (Carvedilol) conversion to CR
    3.125 mg BID
    6.25 mg BID
    12.5mg BID
    25 mg BID
    • 10 mg
    • 20 mg
    • 40 mg
    • 80 mg all doses QD
  50. Lanoxin (Digoxin) 
    tabs?
    sol?
    PK?
    • tabs: yellow 0.125mg, white 0.25mg 
    • sol 50mcg/mL
    • half life = 40hrs do not double up if dose missed
  51. Whats used for Lanoxin (Digoxin) toxicity?
    What are the S/sx?
    • Digibind & Digifab
    • GI upset, slow pulse, visual disturbance,

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