-
What is a normal CD4 count?
500-1500 cells/mm3
-
What is the life cycle of HIV in the body? 6
- attachment to host
- entry
- reverse transcription
- viral integration into host DNA
- viral transcription and translation
- assembly of the vision and budding
-
What is step 1 of HIV diagnosis?
Describe
- Enzyme Immunoassay (EIA)
- screening test for abs to HIV
- result in 60 seconds - 2 days
- 90-99% sensitivity, 99% specificity
-
What is step 2 of HIV diagnosis?
Describe
- Western Blot
- confirmatory test to detect specific abs to each viral antigen
- performed for ALL positive EIA test
- results in 1-2 weeks
- 98% sensitivity, 99% specificity
-
How is AIDS diagnosed?
- A positive test for HIV abs and one or more of the following:
- CD4 T cells < 200 (or CD4 < 14%)
- Any of 25 "AIDs defining conditions"
- see page 14 of 1st packet
- Important for exam!!
-
How many NRTI?
How many NRTI combos?
-
-
How many Protease Inhibitors?
9
-
Name the 2 entry inhibitors?
- Enfuvirtide (ENF,T20) (Fuzeon)
- Maraviroc (MVC) (Selzentry)
-
Name the 2 Integrase inhibitors?
- Raltegravir (RAL) (Isentress)
- Elvitegravir (EVG *only available in Stribild*)
-
How many multiple class combinations?
Name them an what's in them.
- 3
- Atripla (Efavirenz/Emtricitabine/Tenofovir)
- Complera (Rilipvirine/Emtricitabine/Tenofovir)
- Stribild (Elvitegravir/Colbicistat/Emtricitabine/Tenovifir)
-
Abacavir - what is the brand name?
What class?
-
Didanosine - brand?
What class?
-
Emtricitabine - brand?
What class?
-
Lamivudine - brand?
What class?
-
Stavudine - brand?
What class?
-
Tenofovir - brand?
What class?
-
Zidovudine - brand?
Class?
-
What 2 NRTIs are in Epzicom?
- 3TC/ABC
- LAMIVUDINE/ABACAVIR
-
What 3 NRTIs are in Trizvir?
- 3TC/ABC/ZDV
- LAMIVUDINE/ABACAVIR/ZIDOVUDINE
-
What 2 NRTIs are in Combivir?
- 3TC/ZDV
- LAMIVUDINE/ZIDOVUDINE
-
What are the 2 NRTIs in Truvada?
- FTC/TDF
- Emtricitabine/Tenofovir
-
What are the brand names and class?
Delaviridine
Efavirenz
Etravirine
Nevirapine
Rilipvirine
- (DLV) (Rescriptor)
- (EFV) (Sustiva)
- (ETR) (Intellence)
- (NVP) (Viramune)
- (RPV) (Edurant)
- NNRTIs
-
Atazanavir - brand & class?
- (ATV) REYATAZ
- Protease Inhibitors, hence forth referred to as PIs
-
Darunavir - brand & class?
-
Fosamprenavir - brand & class?
-
Indinavir - brand & class?
-
Lopinavir/ritonavir - brand & class?
-
Nelfinavir - brand & class?
-
Ritonavir - brand & class?
-
Saquinavir - brand & class?
-
Tipranavir - brand & class?
-
What are the 3 types of regimens for starting ART?
- 2 NRTIs + 1 NNRTI
- 2 NRTIs + 1 PI (Ritonavir-boosted PI)
- 2 NRTIs + 1 INSTI
-
What is the preferred NNRTI based regimen for treatment naive patients?
- NNRTI based
- Atripla which is:
- (Efavirenz/Emtricitabine/Tenofovir)
-
What is the preferred PI based regimen for treatment naive patients?
- brand name followed by generic:
- Reyataz + Norvir +Truvada (Atazanavir/Ritonavir/(Emtricitabine/Tenofovir)
- or
- Prezista + Norvir + Truvada (Darunavir/Ritonavir/(Emtricitabine/Tenofovir)
-
What is the preferred INSTI based regimen fo treatment naive patients?
- Isentress + Truvada
- Raltegravir + (Emtricitabine/Tenofovir)
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