drugs and MoA

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xinchen3
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202843
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drugs and MoA
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2013-02-26 23:40:35
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drugs MoA
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  1. Cyclosporine
    • Immunosuppressant
    • bind cyclophilin
    • inhibits calcineurin => inhibit IL-2 synthesis
  2. Tarcolimus
    • Immunosuppressant
    • binds FKBP
    • inhibits calcineurin => inhibit IL-2 synthesis
  3. Sirolimus
    • Immunosuppressant
    • bind FKBP
    • inhibits Rapamycin => decrease IL-2 response
  4. Azathioprine
    • Immunosuppressant
    • converted to 6-MP
    • inhibit DNA synthesis
  5. Mycophenolate Mofetil
    • Immunosuppressant
    • inhibits inosine monophosphate DH (IMP-DH)
    • inhibits GTP syntehsis
  6. Leflunomide
    • Immunosuppressant
    • inhibits pyrimidine synthesis
  7. Aldesleukin
    • IL-2 analog
    • activates lymphocytes
  8. Muromonab
    • Immunosuppressant
    • bind CD3
  9. Basiliximab
    • Immunosuppressant
    • bind CD25 (IL-2Ra)
  10. Abatacept
    • Immunosuppressant
    • inhibits CD28-CD80 interaction
  11. Alemtuzumab
    • Immunosuppressant
    • bind CD52
  12. Alefacept
    • Immunosuppressant
    • prevent CD2 & APC interaction
  13. Efalizumab
    • Immunosuppressant
    • inhibits LFA & ICAM
    • inhibits extravascularization of lymphocytes
  14. Natalizumab
    • Immunosuppressant
    • block integrin (tight binding of lymphocytes)
  15. Rituximab
    • Immunosuppressant
    • bind CD20 (CLL)
  16. Entanercept
    Adalimumab
    Inflximab
    • Immunosuppressant
    • block TNF-a
  17. Anakinra
    • Immunosuppressant
    • inhibits IL-1 receptors
  18. methacholine
    • Asthma & COPD
    • ACh agonist (diagnosis only)
  19. Albuterol
    Levalbuterol
    • Asthma & COPD
    • Short acting B2 agonist
  20. Epinephrine
    Metaproterenol
    Terbutaline
    • Asthma & COPD
    • sympathetic agonist
  21. Theophylline
    • Asthma & COPD
    • Adenosine blocker
  22. Beclomethasone
    Fluticasone
    Trimacinolone
    Budesonide
    • Asthma & COPD
    • inhalant corticosteroids
  23. Hydrocortisone
    Prednisone
    • Asthma & COPD
    • Oral Corticosteroid
  24. Salmeterol
    Formoterol
    • Asthma & COPD
    • long acting B2 agonist
  25. Cromolyn sodium
    • Asthma & COPD
    • mast cell stabilizer
    • block Cl- channels
  26. Montelukast
    Zafirlukast
    • Asthma & COPD
    • Leukotriene antagonist
  27. Zileuton
    • Asthma & COPD
    • Lipooxygenase inhibitor
  28. Omalizumab
    • Asthma & COPD
    • anti-IgE antibody
  29. Iprotropium
    Tiotropium
    • mACh inhibitor
    • bronchodilator
  30. Metoclopramide
    Domperidone
    • D2 antagonist => increase ACh
    • cross BBB
    • stimulates GI motility, anti-emetic
  31. Prucalopride
    Tegaserod
    • 5HT4 partial agonist
    • stimulates GI motility
  32. Bethanechol
    • ACh agonist
    • stimulates GI motility
  33. Erythromycin
    • macrolide antibiotic
    • mimics motilin
    • stimulates GI motility
  34. Lubiprostone
    • activates Cl- channels in GI
    • stimulate GI motility
  35. Methylcellulose
    Psyllium
    bulk forming laxative
  36. Bisacodyl
    Senna
    Castor oil
    • stimulant/irritant laxative
    • activate cAMP & GMP
    • inhibits Na/K ATPase
  37. Magnesium hydroxide
    Polyethylene Glycol
    Lactulose
    osmotic laxative
  38. Docusate
    • surfactant laxative
    • stimulate GI fluid and electrolyte secretion
  39. Glycerine suppositories
    Liquid paraffin
    lubricant laxative
  40. Ondansetron
    • 5HT3 blocker
    • anti-emetic (cancer treatment)
  41. Granisertron
    • 5HT3 blocker
    • anti-emetic (cancer treatment)
  42. Dolasetron
    • 5HT3 blocker
    • anti-emetic (cancer treatment)
  43. Dronabinol
    Nabilone
    • cannabinoid receptor agonist
    • anti-emetic (cancer treatment)
    • stimulates appetite
  44. Scopolamine
    • Anti-Emetic
    • anti-cholinergic
    • motion sickness
  45. Diphenydramine
    Promethazine
    • Anti-Emetic
    • 1st gen H1 blocker
    • motion sickness
  46. Aprepitant
    • Anti-Emetic
    • substance P antagonist
  47. Ursodeoxycholic acid (UDCA)
    • synthetic bile acid
    • treat gall stones
  48. Mesalamine
    • like aspirin
    • treat UC
  49. Pancrealipase
    • pancreatic enzyme mixture
    • enzyme replacement in chronic pancreatitis (CF)
  50. Orlistat
    • inhibit pancreatic lipase
    • weight loss therapy
  51. Latanoprost
    Bimatroprost
    Travoprost
    • Glaucoma
    • PGF2a analog
    • increase aqueous humor outflow (Glaucoma)
  52. Timolol
    metipranolol
    betaxolol
    • Glaucoma
    • beta-blockers
    • decrease aqueous humor production
  53. Apraclonidine
    Bromonidine
    • Glaucoma
    • alpha2-agonist
    • Decrease aqueous humor production
    • increase aqueous humor outflow
  54. Acetazolamide
    Dorzolamide
    • Glaucoma
    • carbonic anhydrase inhibitor
    • decrease aqueous humor production
  55. Pilocarpine
    Carbachol
    • Glaucoma
    • ACh agonist
    • increase aqueous humor outflow
    • not for close angle glaucoma
  56. Phenytoin
    • Anti-Epileptic
    • prolong Na channel inactivation
  57. Carbamazepine
    • Anti-Epileptic
    • prolong Na channel inactivation
    • increase ADH release
  58. Valporate
    • Anti-Epileptic
    • prolong Na channel inactivation
    • inhibits T-type Ca2+ channels
    • inhibit GABA transaminase
    • inhibit glutamate receptors
  59. Zonisamide
    • Anti-Epileptic
    • prolong Na channel inactivation
    • inhibit T-type Ca channel
  60. Ethosuximide
    • Anti-Epileptic
    • inhibit T-type Ca channel
  61. Lamotrigine
    • Anti-Epileptic
    • prolong Na channel inactivation
    • inhibit T-type Ca channel
    • inhibits glutamate receptor
  62. Topiramate
    • Anti-Epileptic
    • prolong Na channel inactivation
    • Potentiate GABA channels
    • inhibits AMPA receptor
    • carbonic anhydrase inhibitor
  63. Gabapentin
    Pregabalin
    • Anti-Epileptic
    • increase GABA release
  64. Vigabatrin
    • Anti-Epileptic
    • inhibit GABA transaminase
  65. Tiagabine
    • Anti-Epileptic
    • inhibit GABA reuptake
  66. Levetiracetam
    • Anti-Epileptic
    • increase GABA
    • decrease glutamate
  67. Felbamate
    • Anti-Epileptic
    • inhibit glutamate
    • potentiate GABA
  68. Imipramine
    Desipramine
    • Depression treatment
    • TCAs
    • inhibits NE & Serotonin reuptake
    • (also inhibits H1, a1, & M1)
  69. Amitriptyline
    Nortriptyline
    • Depression treatment
    • TCAs
    • inhibits NE & Serotonin reuptake
    • (also inhibits H1, a1, & M1)
  70. Clomipramine
    • Depression treatment
    • TCAs
    • inhibits NE & Serotonin reuptake
    • (also inhibits H1, a1, & M1)
  71. Fluoxetine
    • Depression treatment
    • SSRI
  72. Fluvoxamine
    • Depression treatment
    • SSRI
  73. Paroxetine
    • Depression treatment
    • SSRI
  74. Sertraline
    • Depression treatment
    • SSRI
  75. Citalopram
    • Depression treatment
    • SSRI
  76. Escitalopram
    • Depression treatment
    • SSRI
  77. Venlafaxine
    • Depression treatment
    • SNRI
  78. Desvenlafaxine
    • Depression treatment
    • SNRI
  79. Duloxetine
    • Depression treatment
    • SNRI
  80. Bupropion
    • Depression treatment
    • NE & Dopamine reuptake inhibitor
  81. Maprotiline
    • Depression treatment
    • NE reuptake inhibitor
  82. Reboxitine
    • Depression treatment
    • NE reuptake inhibitor
  83. Mirtazapine
    • Depression treatment
    • NE & Serotonin reuptake inhibitor
  84. Trazodone
    • Depression treatment
    • Serotonin reuptake inhibitor (more specific)
  85. Nefazodone
    • Depression treatment
    • Serotonin reuptake inhibitor (more specific)
  86. Phenelzine
    • Depression treatment
    • non-selective MAO inhibitor
  87. Tranylcypromine
    • Depression treatment
    • non-selective MAO inhibitor
  88. Moclobemide
    • Depression treatment
    • reversible MAO-A inhibitor
  89. Selegiline
    • Depression treatment
    • Irreversible MAO-B inhibitor
  90. Lithium
    • Bipolar treatment
    • inhibits phosphoinositides recycling
  91. Chlorpromazine
    Thioridazine
    Trifluoperazine
    Fluphenazine
    Perphenazine
    • anti-psychotic
    • block D2, 5HT, a1, M1, H1
  92. Haloperidol
    • anti-psychotic
    • block D2
  93. Clozapine
    • atypical anti-psychotics
    • block D2, 5HT, a1, M1, H1
  94. Olanzapine
    • atypical anti-psychotics
    • block D2, 5HT, a1, M1, H1
  95. Risperidone
    • atypical anti-psychotics
    • block D2, 5HT, a1
  96. Ziprasidone
    • atypical anti-psychotics
    • block D2, 5HT
  97. Quetiapine
    • atypical anti-psychotics
    • block D2, 5HT, a1, H1
  98. Aripiprazole
    • atypical anti-psychotic
    • partial D2 agonist
  99. Levodopa
    • Parkinson's
    • increase CNS dopamine
  100. Carbidopa
    • Parkinson's
    • use with L-Dopa, to prevent peripheral ADCC degradation of L-Dopa
  101. Apomorphine
    • Parkinson's
    • Dopamine agonist
    • prevent L-Dopa flucturation
  102. Bromocriptine
    • Parkinson's
    • Dopamine agonist
  103. Pramipexole
    • Parkinson's
    • Dopamine agonist
  104. Ropinirole
    • Parkinson's
    • Dopamine agonist
  105. Amantadine
    • Parkinson's
    • stimulates dopamine release
    • inhibit DA reuptake
  106. Selegiline
    • Parkinson's
    • MAO-B inhibitor
  107. Rasagiline
    • Parkinson's
    • MAO-B inhibitor
  108. Entacapone
    • Parkinson's
    • COMT inhibitor
  109. Tolcapone
    • Parkinson's
    • COMT inhibitor
  110. Trihexylphenidyl
    • Parkinson's
    • Anti-cholinergic
  111. Benztropine
    • Parkinson's
    • Anti-cholinergic
  112. Reserpine
    • Huntington's
    • inhibits VMAT - no NE & DA release
  113. Tetrabenazine
    • Huntington's
    • inhibits VMAT - no NE & DA release
  114. Anti-Psychotics
    - Haloperidol, Fluphenazine, Perphenazine
    • Huntington's
    • D2 blockers
  115. Donepezil
    • Alzheimer's
    • Cholinesterase inhibitor
  116. Galantamine
    • Alzheimer's
    • Cholinesterase inhibitor
  117. Rivastigmine
    • Alzheimer's
    • Cholinesterase inhibitor
  118. Tacrine
    • Alzheimer's
    • Cholinesterase inhibitor
  119. Memantine
    • Alzheimer's
    • NMDA inhibitor
  120. Methylphenidate
    • ADHD
    • inhibits NE & DA reuptake
  121. Amphetamines
    • ADHD
    • stimulates DA release
    • inhibits DA reuptake
    • inhibits MAO
  122. Atomoxetine
    • ADHD
    • inhibits NE reuptake
  123. a2-agonist
    - Clonidine, Guanfacine
    ADHD

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