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Having or pertaining to the ability to destroy or interfere with the development of a living organism. The term is used most commonly to refer to antibacterial drugs. (p. 585)
One of two types of topical antimicrobial agent; a chemical that inhibits the growth and reproduction of microorganisms without necessarily killing them. Antiseptics are also called static agents. (p. 586)
Antibiotics that kill bacteria. (p. 591)
Antibiotics that do not actually kill bacteria but rather inhibit their growth. (p. 589)
"The designation for a broad, major class of antibiotics that includes four subclasses: penicillins, cephalosporins, carbapenems, and monobactams; so named because of the beta-lactam ring that is part of the chemical structure of all drugs in this class. (p. 590)"
Any of a group of enzymes produced by bacteria that catalyze the chemical opening of the crucial beta-lactam ring structures in beta-lactam antibiotics. (p. 590)
Medications combined with certain penicillin drugs to block the effect of beta-lactamase enzymes. (p. 590)
"The establishment and growth of microorganisms on the skin, open wounds, or mucous membranes, or in secretions without causing adverse clinical signs or symptoms. (p. 586)"
An infection that is acquired by persons who have not been hospitalized or had a medical procedure recently (within the past year). (p. 586)
The administration of antibiotics based on known results of culture and sensitivity testing identifying the pathogen causing infection. (p. 587) (al 584-585)
One of two types of topical antimicrobial agent; a chemical applied to nonliving objects to kill microorganisms. Also called cidal agents. (p. 586)
The administration of antibiotics based on the practitioner's judgment of the pathogens most likely to be causing an apparent infection; it involves the presumptive treatment of an infection to avoid treatment delay before specific culture information has been obtained. (p. 587)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
"An inherited disorder in which the red blood cells are partially or completely deficient in glucose-6-phosphate dehydrogenase, a critical enzyme in the metabolism of glucose. Certain medications can cause hemolytic anemia in patients with this disorder. This is an example of a host factor related to drug therapy. (p. 588)"
Health careassociated infection
An infection that is acquired during the course of receiving treatment for another condition in a health care facility. The infection is not present or incubating at the time of admission. (p. 586)
Factors that are unique to the body of a particular patient that affect the patient's susceptibility to infection and response to various antibiotic drugs. (p. 588)
Invasions and multiplications of microorganisms in body tissues. (p. 585)
Microscopic living organisms (also called microbes). (p. 585)
Prophylactic antibiotic therapy
Antibiotics taken before anticipated exposure to an infectious organism in an effort to prevent the development of infection. (p. 587)
A necrotizing inflammatory bowel condition that is often associated with antibiotic therapy. A more general term that is also used is antibiotic-associated colitis. (p. 587)
A common genetic host factor in which the rate of metabolism of certain drugs is reduced. (p. 588)
"Referring to antibiotic treatment that is ineffective in treating a given infection. Possible causes include inappropriate drug therapy, insufficient drug dosing, and bacterial drug resistance. (p. 587)"
"(1) An infection occurring during antimicrobial treatment for another infection, resulting from overgrowth of an organism not susceptible to the antibiotic used. (2) A secondary microbial infection that occurs in addition to an earlier primary infection, often due to weakening of the patient's immune system function by the first infection. (p. 587)"
Substances that can interfere with normal prenatal development and cause one or more developmental abnormalities in the fetus. (p. 588)
Referring to antibiotic therapy that results in sufficient concentrations of the drug in the blood or other tissues to render it effective against specific bacterial pathogens. (al 585)
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