Defend or argue against the following statement. Genome/chromatin modifications in the parent are never passed on to the offspring. Alternatively this might be worded as, with each fertilization, the genome slate is wiped clean. Answers to either should be in terms of epigenetics, imprinting, etc.
- Chromatin modification may be present in the offspring, as the DNA sequences that may be present and passed on through transposition or tandem duplications, in which the child inherits these DNA sequences, may result in similar modifications.
- Modifications that can be inherited may result from the inherited DNA sequences leading to:
- 1. the same chromatin structure formation due to modifications of histone tails, or RITS-RNA incuded transcriptional silencing for example.
- 2. similar targets for DNA methylation and other histone modifications