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  1. Class:
  2. Mechanism of action
    Directing-acting alpha- and beta-agonist. Alpha vasoconstriction. Beta-1 postive intropic, chronotropic, and dromotropic effects. Beta-2 bronchial smooth muscle relaxation and dilation of skeletal vasculature.
  3. Indications
    Cardiac arrest (V fib/pulseless V-tach, asystole, PEA), symptomatic bradycardia as an alternative infusion to dopamine severe hypotension secondary to bradycardia when atropine and transcutaneous pacing are unsuccessful, allergic reactions, anaphylaxis, asthma.
  4. Contraindications
    Hypertension, hypothermia, pulmonary edema, myocardial ischemia, hypovolemic shock.
  5. Adverse reactions
    Hypertension, tachycardia, arrhythmias, pulmonary edema, anxiety, restlessness, psychomotor agitation, nausea, headache, angina.
  6. Drug interactions
    Potentiates other sympathomimetics, deactivated by alkaline solutions (ie, sodium bicarbonate) , monamine oxidase inhibitors (MAOIs) may poteniate effects, beta blockers may blunt effects.
  7. How supplied
    1:1000 solution : ampules and vials containing 1mg/ml. 1:10,000 solution: prefilled syringes containing 1 mg in 10 ml (0.1 mg/ml). Auto-injector (EpiPen): 0.5mg/ml (1:2,000).
  8. Dosage and adminstration
    Adult: Mild allergic reactions and asthma: 0.3-0.5mg (0.3-0.5 ml of 1:1000) SC. Anaphylaxis ).1 mg(1 ml of 1:10,000) IV/IO over 5 minutes. Cardiac arrest: IV/IO dose: 1mg (10ml 1:10,000 solution) every 3-5minutes during resucitation.
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