Home > Flashcards > Print Preview
The flashcards below were created by user
on FreezingBlue Flashcards. What would you like to do?
What are the names of the two ANTITUMOR ANTIBIOTICS?
What is the brand name for Doxorubicin?
Doxorubicin - MOA
which can intercalate between base pairs, inhibit topoisomerase II
, and generate free radicals
, binding to cellular membranes to alter fluidity and ion transport
- • Blocks the synthesis of RNA and DNA
- and causes DNA strand scission.
Doxorubicin - CCNS or CCS?
Doxorubicin – Pharmacokinetics
•Must be given IV.
- •Metabolized in the liver and excreted in
- the urine, imparting to it a red color.
Doxorubicin - Clinical use
- acute leukemia,
- and ovary
Doxorubicin – Toxicity
- GI distress,
- and alopecia.
- Unique side effect is cardiotoxicity.
Bleomycin - MOA
- acts by binding to DNA, which results in
- single-strand and double-strand breaks following free radical formation, and inhibition of DNA biosynthesis
- Cell cycle-specific drug that causes
- accumulation of cells in the G2 phase of the cell cycle.
Bleomycin - Clinical treatment of
- Hodgkin's and non-Hodgkin's lymphomas,
- germ cell tumor,
- head and neck cancer,
- and squamous cell cancer of the skin, cervix, and vulva.
Bleomycin - Pharmokinetics
May be given IV, IM, or SQ
Bleomycin - Toxicity
Plant Alkaloids are CCS drugs which include?
- vinca alkaloids,
- the podophyllotoxins,
- and the taxenes.
Brand name for Vincristine?
Vincristine - MOA
A spindle poison derived from the periwinkle plant. Prevents the assembly of tubulin dimers into microtubules, and blocks the formation of the mitotic spindle.
Acts on the M phase of the cell cycle
Vincristine – Resistance
occurs as a result of increased efflux from the cell by a transporter molecule.
Vincristine – Pharmacokinetics
- Given IV.
- Good tissue penetration except into the CSF.
- Cleared mainly by biliary excretion
Vincristine - Clinical use
- Hodgkin’s disease,
- Wilm’s tumor,
- childhood acute leukemia
Vincristine – Toxicity
- GI distress,
- Peripheral neuropathy.
What type of plant alkaloid is Etoposide?
- a podophyllotoxin
- derived from the May apple plant
Etoposide - MOA
- Interacts with Topoisomerase II to increase the degradation of DNA.
- - Most active in the late S and early G2 phases.
Etoposide – Pharmacokinetics
- Good oral absorption,
- eliminated via the kidney
Etoposide – Toxicity
Etoposide - Clinical use
- treat germ cell cancers,
- small cell and non-small cell lung cancers,
- Hodgkin’s and non-Hodgkin’s lymphomas,
- and gastric cancer.
Brand name for Paclitaxel?
Paclitaxel - What type of plant alkaloid is it?
- A taxane derived from the Pacific yew tree.
Paclitaxel - MOA
- Mitotic spindle poison,
- M phase specific
Paclitaxel - Clinical use
Breast and ovarian cancer
Paclitaxel – Toxicity
- and hypersensitivity reactions
What are SERM’s?
SERM’s are mixed estrogen agonists that act as antagonists in certain tissues
Name two hormones used in the treatment of cancer.
- Tamoxifen (Nolvadex)
Prednisone is used to treat?
- acute leukemia,
- Hodgkin’s disease,
- and lymphoma
Brand name for Tamoxifen?
Tamoxifen - MOA
- Selective Estrogen Receptor Modifier
- (SERM) which blocks the binding of estrogen to receptors of estrogen-sensitive cancer cells in breast tissue.
- acts as an antagonist in hormone-responsive breast cancers where it prevents receptor activation by endogenous estrogen.
Tamoxifen - Clinical use
- Used in the treatment of receptor-positive breast cancers and may help prevent cancer in high risk women.
- has more agonist than antagonist action on bone and thus helps to prevent osteoporosis.
Tamoxifen - Toxicity
- hot flushes,
- vaginal bleeding,
- and peripheral edema.
Interferon alfa-2 - MOA
- Made by lymphocytes,
- inhibits cell proliferation,
Interferon alfa-2 - Clinical use
- hairy cell leukemia,
- Kaposi’s sarcoma,
- and hepatitis.
Interferon alfa-2 - Side effects
- –Causes flu-like symptoms,
Imatinib - MOA
- the first member of a new class of drugs that act by specifically inhibiting an enzyme that is characteristic of a cancer cell rather than non-specifically killing all rapidly dividing cells.
- inhibitor of the tyrosine kinase domain of the Bcr-Abl oncoprotein
Imatinib - Clinical use
Indication - chronic myelogenous leukemia (CML),
- - Given orally,
- - Metabolized by CYP3A4
What does EGFR stand for?
Epidermal growth factor receptor
What is the anticancer drug classified as an
Epidermal growth factor receptor inhibitor?
Cetuximab - Clinical use
metastatic colon cancer
Cetuximab - Toxicity
- Acneiform skin rash,
- and hypomagnesemia
What does VEGF stand for?
vascular endothelial growth factor
- - (VEGF) is one of the most important angiogenic growth factors. The growth of both primary and metastatic tumors requires an
- intact vasculature. As a result, the VEGF-signaling pathway represents an
- attractive target for chemotherapy.
Bevacizumab - MOA
- Bevacizumab is a recombinant humanized monoclonal antibody that targets all forms of VEGF-A.
- This antibody binds to and prevents VEGF-A from interacting with the target VEGF receptors.
Bevacizumab - Clinical use
- can be safely and effectively combined with 5-FU-, irinotecan-, and oxaliplatin-based chemotherapy
- - in the treatment of
- metastatic colorectal cancer.
Name 3 drugs used to treat renal cell cancer.