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Sodium ECF concentration?
Calcium ECF concentration?
Glucose ECF concentration?
- Fasting 3.5-6 mmol/L
- Non fasting 3.5-8 mmol/L
Potassium ECF concentration?
Core body temperature?
About 37C (36-38C)
Sodium ECF function? (3)
- Main extracellular cation
- Determines ECF volume and therefore influences blood pressure
- Action potential generation - nerve/muscle
Calcium ECF function? (4)
- Structural component - bone and teeth
- Neurotransmission and muscle contraction
- Regulates enzyme function
Glucose function? (1)
Used by cells - produce adenosine triphosphate (ATP)
Potassium ECF function? (2)
- Most abundant ICF cation
- Determinant resting membrane potential
Low core body temperature issues? (2)
- Chemical reactions slow down preventing cell function
- Complete loss of temperature regulation
High core body temperature issues? (2)
- Denaturing of enzymes
- Temperature regulation impairment
Passive membrane transport systems? (3)
- Simple diffusion
- Simple diffusion via membrane channels
- Carrier mediated passive transport
Osmolarity of ECF/ICF?
Measure of total number solute particles per litre of solution in osmol/L
Define tonicity and how it is influenced.
- Effect a specific solution has on cell volume.
- Influenced by type of solution - specifically whether solute particles can cross cell membrane
Describe effect of Isotonic solution.
No change in cell volume
Describe effect of Hypotonic solution.
Increase in cell volume - cells will swell
Describe effect of Hypertonic solution.
Loss of cell volume - cells will shrink
The maintenance of relatively constant conditions in the internal environment if the face of external or internal change.
Describe the sodium-potassium pump and its function.
- An active cell membrane transport system that moves 3 sodium ions out of the cell in exchange of 2 potassium ions.
- Maintains ionic gradients and helps regulate cell volume.
Amount of solute particles per kg of water in osmol/kg.
Describe hyperosmotic solution.
Higher solute concentration than cell
Describe hypoosmotic solution.
Lower solute concentration than cell
Describe isoosmotic solution.
Same solute concentration as cell
What is the body water % for males and females by weight?
What % of total body water does ECF contribute?
What % of total body water does ICF contribute?
What % of ECF does blood plasma contribute?
What % of ECF does interstitial fluid contribute?