Apical, basal and Nuculas
Goblet cells are glandular epithelial cells – found predominantly in the lining of the digestive and respiratory tracts – whose sole purpose is the secretion of mucus. Mucus is a sticky, viscous substance composed of mucins, enzymes, and electrolytes suspended in water. It coats the epithelium of vulnerable structures to protect them from chemical or mechanical damage, and to trap invading pathogens.When viewed on slides, goblet cells are usually seen to be goblet-shaped, hence the moniker. They appear narrow at the base, where the nucleus and other organelles are found, and enlarged at the apical portion where the mucus-secreting granules are located. The characteristic shape is actually a result of the expansion of mucus-filled granules during the fixation process, and when care is taken in slide preparation the cells typically appear as simple columnar cells.