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What are the primary functions of the immune system, and consequently how can it go wrong?
- Protect the body from foreign invasion- has the ability to identify self from non-self
- Clean up debris- isolate and phagocytosis
- Prepare tissue for healing-inflammation, tissue restoration or scarring
Which antibodies are responsible for recognizing foreign invaders
T lymphocytes and B lymphocytes can recognize any foreign antigen to fight infection
What do kinins/bardykinins do?
- Cause inflammation
- Wall off pathogens
Organs of immunity: thymus
T Lymphocytes migrate to the thymus to mature and then are released into circulation
Organs of immunity: spleen
- Lymph filtration
- Recycles iron from RBCs
- White cells for blood borne protection
- Blood reservoir
What do you need to know about leukocytes
- Granulocytes (55-60%)
- Named after granules in the cytoplasm and perform phagocytosis
- Immature Neutrophils are called “Bands”, requiring 14 days for maturity
What do you need to know about granulocytes?
- Lymphocytes- Granulocytes with “Natural Killer”
- abilities- small Lymphocytes are T and B Cells
What type of granulocyte is involved in allergic rxn and parasite invasion?
What is a basophil?
stimulate inflammatory response- have histamine, bradykinin and heparin granules
Mast cells are basophils found in the tissues
What's a neutorphil?
- Chief phagocytes of early inflammation
- Shoot lysosmal granules dissolve cellular debris to prepare site for wound healing
What are agranulocytes?
- Most powerful at phagocytosis
- Do not contain granules, can ingest dead host cells such as blood cells
- Monocytes and macrophages are agranulocytes
- Monocyte is immature macrophage
- --replenish macrophages
- --respond quickly to inflammation
What do macrophages do?
- Significantly initiate inflammatory response
- Larger and more phagocytic than monocytes