med chem III quiz 5 antiinflammatory

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med chem III quiz 5 antiinflammatory
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2013-03-06 07:42:53
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med chem III quiz 5 antiinflammatory
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  1. 2 NSAID sulfonamides
    • piroxicam - feldene
    • meloxicam - mobic
  2. NSAID COX-2 selective
    celecoxib - celebrex
  3. 5-HT1D agonist for migraine
    sumatriptan - imitrex
  4. 5-HT2A/2C antagonist for migraine and depression
    methysergide
  5. serotonin 5-HT1 agonist
    not for prophylaxis
    dosing must be nor more often than q2h
    rizatriptan - maxalt
  6. serotonin 5-HT1 agonist
    use extreme caution in hepatic failure can result in extreme BP elevation
    zolmitriptan - zomig
  7. serotonin 5-HT1 agonist
    more selective
    metabolized by MAO & CYP3A4 &2D6
    almotriptan - axert
  8. serotonin 5-HT1 agonist
    contraindicated in pts with severe renal or hepatic failure
    naratriptan - amerge
  9. serotonin 5-HT1 agonist
    ind - acute Tx of migraine attacks w/ or w/o aura
    26 hr 1/2 life - better compliance - 1tab Tx
    frovatriptan - frova
  10. serotonin 5-HT1B/1D agonist
    not for prophylaxis
    CI in ischemic heart disease
    eletriptan - relpax
  11. ergot alkaloid
    most famous
    schedule 1
    LSD
  12. ergot amino derivative
    nasal spray
    hihydroergotamine mesylate - migranal
  13. ergot amino derivative
    ergotamine tartrate - ergomar
  14. chronic migraine dealing with head skin pain
    onabotulinumtoxin A - botox
  15. sensation of whirling or rotating accompanied by involuntary swaying, weakness and lightheadedness
    vertigo
  16. functional disorder caused by repetitive angular, linear or vertical motion
    motion sickness
  17. antidopaminergic
    phenothiazine
    ind- intracable hiccoughs
    SE thorazine shuffle
    CI in < 6mo, unless life saving
    chlorpromazine
  18. antidopaminergic
    phenothiazine
    ind- antihistamine for type I hypersensitivity & motion sickness (pre&post surgery)
    promethazine
  19. antidopaminergic
    non-phenothiazine
    ind - N/V in cancer chemotherapy & preg & labor
    metoclopramide - reglan
  20. given if extrapyramidal symptoms occur from reglan
    50mg diphenhydramine IM
  21. anticholinergic
    antihistamine
    piperazine
    ind - motion sickness
    CI with morphine or resp. depressants
    meclizine - antivert
  22. anticholinergic
    antihistamne
    ind - N/V
    oral use only antihistamine
    moa - depressant action on the hyperstimulated labyrinthine
    diphenhydramine - benadryl (oral)
  23. anticholinergic
    moa - obscure (may inhibit CTZ but direct signals to the VC are NOT)
    trimethobenzamide - tigan
  24. anticholinergic
    ind - motions sickness
    not for children
    dry mouth, caution in parkinson pts
    scopolamine - transderm-scop
  25. 5-HT1A partial agonist for anxiety and depression
    no anticonvulsant activity or muscle relaxant properties
    3-4 wks to see results
    buspirone
  26. 5-HT3 antagonist for chemo-induced emesis
    N/V due to APAP poisoning
    oral disintegrating tabs
    ondansetron - zofran
  27. 5-HT4 agonist for GI disorders
    cisapride
  28. 5-HT transporter inhibitor for depression, O/C, panic, PTSD
    • fluoxetine
    • sertraline
  29. 5-HT3 anagonist
    caution in pts w/ QT abnormalities, taking diuretics
    don't mix IV with other drugs
    can mix w/ apple/grape juice for peds
    dolasetron - anzemet
  30. 5-HT3 anagonist
    tab, inj, transdermal
    monitor liver cancer pts carefully
    • granisetron
    • sancuso - transdermal
  31. 5-HT3 anagonist
    ind - irritable bowel syndrome (women only)
    tab
    SE severe constipation leading to perforated colon
    alosetron - lotronex
  32. 5-HT3 anagonist
    N/V cancer chemotherapy 30 min prior
    not recommended to redose within 7d
    no CYP induction or inhibition
    palonosetron - aloxi
  33. 5-HT4 partial agonist
    available through special access programs
    short term Tx IBS in women
    not for diarrhea-prominent IBS
    tegaserod - zelnorm
  34. cannibinoid
    ind - antiemetic cancer chemotherapy
    schedule 3
    unlabeled - appetite stimulation (AIDS pts)
    pts remain under supervision of adult
    dronabinol - marinol
  35. cannibinoid
    oral synthetic
    ind - antiemetic cancer chemotherapy
    schedule 2
    <1% reaches the brain, CYP metabolized
    nabilone - cesamet
  36. substance P/neurokinin 1 receptor antagonist
    N/V chemotherapy including high dose cisplatin
    augments 5-HT3 antagonist activity
    aprepitant - emend
  37. misc. agent
    ind - N/V from intestinal and stomach flu
    and food and drink indiscretions
    emetrol
  38. anti-anxiety
    BZ
    ind - PMS, panic disorder w/ or w/o agoraphobia
    alprazolam - xanax
  39. anti-anxiety
    BZ
    ind - adjunct in partial seizures
    clorazepate dipotassium - gen-Xene
  40. anti-anxiety
    BZ
    ind - preoperative apprehension
    chlordiazepoxide - libruim
  41. anti-anxiety
    BZ
    muscle relaxant
    solution, tab, inj, rectal gel
    diazepam - valium
  42. anti-anxiety
    BZ
    ind -status epilepticus
    chronic insomnia
    tab, inj, sol
    lorazepam - ativan
  43. anti-anxiety
    BZ
    ind - alcoholics with acute tremulouness
    caps
    oxazepam
  44. anti-anxiety
    ind - psychoneurosis pts - sleep disturbances
    TCAD with anti-anxiety properties
    not recommended for <12yo
    doxepin - silenor
  45. anti-anxiety
    ind - prior to dental appt
    moa - subcortical area CNS depressant-ataraxic
    tab,cap, syrup, susp inj
    hydroxyzine - vistaril
  46. anti-anxiety
    ind  - effectiveness of >4 mo unknown
    moa- carbamate derivative
    may precipitate seizures in epilepsy, slowly withdraw
    meprobamate
  47. 2 salicylates not hydrolyzed to salicylic acid
    • salicyamide
    • diflunisal
  48. lethal doses of salicylic acid
    • adults - 10-30 grams
    • children - 4 grams
  49. non-selective COX inhibitor
    swallow tabs whole, no chewing
    diflunisal
  50. 2 NSAIDs not used for RA of osteoarthritis
    • ketorolac
    • mefenamic acid
  51. synthesized continuously COX
    1
  52. inducible COX
    2
  53. NSAID
    acetic acid 6
    • sulindac - clinoril
    • indomethacin - indocin
    • etodolac
    • tolmetin
    • nabumetone
    • diclofenac - voltaren
  54. NSAID
    proprionic 7
    • ketorolac
    • ibuprofen - advil
    • fenoprofen - nalfen
    • ketoprofen - nexcede
    • flurbiprofen - ansaid
    • naproxen - aleve
    • oxaprozin - daypro
  55. NSAID
    acetic
    prodrug
    nabumetone
  56. NSAID
    acetic
    patch, gel, combo w/ misoprostol
    flector, voltaren, arthrotec
  57. NSAID
    propionic
    first intranasal
    sprix
  58. NSAID
    N-Arylanthranilic acid
    fenamic acid derivative
    mefenamic acid - ponstel

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