CNS Stimulants

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Author:
mp
ID:
205234
Filename:
CNS Stimulants
Updated:
2013-03-05 21:02:40
Tags:
Pharmacology II CNS Stimulants
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Description:
CNS Stimulants
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  1. Amphetamines moa
    Release of NE, DA and 5HT
  2. Effects of Amphetamine
    • increased arousal and wakefullness
    • mood alteration
    • insomnia
    • anorexia
  3. Therapeutic Uses of Amphetamines
    • management of ADHD -- increases attention span
    • Treatment of Narcolepsy
    • Analgesia
    • Antidepressant -- NOT FDA approved
  4. Amphetamines adverse effects
    • CNS stimulation
    • Wt loss
    • CV effects
    • Psychosis
  5. Methylphenidate (Ritalin)
    Dexmethylphenidate (Focalin)
    • blocks reuptake of NE and DA
    • similar to pharmacology of amphetamines
  6. Atomoxetine -- moa
    • selective inhibition of NE reuptake
    • also, alpha-2 agonist effect in CNS
    • Nonstimulant
    • No potential for abuse
  7. Atomoxetine -- adverse effects
    • GI rxns
    • dizziness
    • somnolence
    • mood swings
  8. TCAs in ADHD
    • decrease hyperactivity
    • little effect on impulsivity and inattention
    • 2nd line drugs
  9. Buproprion (Wellbutrin) in ADHD
    • can reduce behavioral symptoms
    • less effective than stimulants
    • risk of seizures
    • 2nd line drugs
  10. Phentermine (Ionamin)
    • amphetamine like drug
    • appetite suppression
    • increases synaptic 5HT
  11. Phenylpropanolamine
    • amphetamine like drug
    • decongestant agent
    • mild degrees of CNS stimulation
    • risk of hemorrhagic stroke
  12. Ephedrine (ma huang)
    • amphetamine like drug
    • increased health risk -- HTN, palpitations, tachycardia, stroke and seizures
  13. Lorcaserin (Belviq)
    selective 5HT2c receptor agonist
  14. Xanthine (Methylxanthines)
    • reversible block of adenosine receptors
    • also inhibits PPD which increases cAMP
  15. Modafinil (Provigil)
    • enhances NE and DA by unknown mechanism
    • promotes wakefullness
    • unlabeled uses in ADHD and fatigue in MS
    • S/E: diarrhea, rhinitis, HA and N

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