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BIO immunity
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how are antibodies held together
disulfide bonds
how are antigens made
four peptide chains
two heavey
two light
how many binding sites do antibodies have
2 (Fab)
constant region =
Fc
important to know IgA can be
Dimer and Monomer
IgM has how many binding sites
10
IgD is a
monomer
2 binding sites
IgE is a...
monomer
IgM is a
Pentamer
Which Antibodies go throught the compliment cascade
IgG
IgA
which antibody can cross the placenta
IgG
which Antibodies fix compliment
IgG
IgM
which antibody is in greatest concentration in serum
IgG 80%
IgG structure =
monomer
Compliment helps antibodies be
more effective
IgG function =
enhances phagocytosis
neutralizes toxins and viruses
protects fetus and newborn
IgM structure =
pentamer
binding sites = 10
functions of IgM=
first antibody produced during primary infection
effective against microbes and agglutinating antigens
IgA antibody function =
Localized protection of mucosal surfaces. Provides immunity to infant digestive tract
only one that goes throgh milk
IgA structure =
Dimer or Monomer
which antibody do they know the least about =
IgD
IgD structure =
monomer
IgG structure =
monomer
functions of IgE
allergic reactions
possibly lysis of worms
functions of antibodies =
tagged bacterial cells
opsonization =engulfed easier by phagocytes
neutralization = block binding sites of viruses
agglutination = block spread
complement fixation
Precipitation = antibodies aggregate antigen molecules
4 types of acquiring immunity =
Natural active = exposed to antigen
Natural passive = exposed to antibody
Artificial active = injected with antigen
Artificial passive = injected with antibody
artificial active immunity =
injected with antigen (flu shot
natural active immunity =
exposed to infections
natural passive immunity
exposed to antibody
mother milk IgG
IgA colostrum
Active passive immunity =
anti-venom
Rhogam shots
no immunological memory
attentuated =
causes immune reponse but not actual infection (organism is live)
two types of active vaccinations =
killed whole cell
attenuated
compare inactivated vs attenuated vaccine
INACTIVATED
•Dead organisms are safest
•Generally less effective immunogens
•Wrong portal of entry
ATTENUATED
•Live organisms offer better response
•Mimic actual infection
•May mutate back to virulent form
Author
Anonymous
ID
205883
Card Set
BIO immunity
Description
BIO immunity
Updated
3/8/2013, 5:33:11 PM
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