Lipids and Lipoproteins

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Author:
ncrook
ID:
206516
Filename:
Lipids and Lipoproteins
Updated:
2013-05-04 16:16:48
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Lipid Test Methodologies
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Description:
Lipid Test Methodologies
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  1. What clinical conditions are linked to elevated levels of cholesterol?
    • Atherosclerosis
    • Coronary artery disease
    • Increased risk for myocardial infarction
  2. What clinical conditions are linked to decreased levels of cholesterol?
    • Liver disease
    • Alcoholic cirrhosis
  3. What test methodology is used to measure cholesterol?
    Enzymatic methodology
  4. What clinical conditions are associated with increased HDL?
    Decreased risk of coronary artery disease
  5. What clinical conditions are associated with decreased HDL?
    Increased risk of coronary artery disease
  6. What test methodologies are used to measure HDL?
    • Precipitate LDL and VLDL cholesterol then assay the supernatant using enzymatic technique
    • Homogeneous assay
  7. What clinical conditions are associated with LDL?
    • Atherosclerosis
    • Coronary heart disease
  8. What test methodologies are used to measure LDL?
    • Calculation (Friedwald formula)
    • Directly (Homogeneous assay)
  9. What is the Friedwald formula used to calculate LDL?
  10. What clinical conditions are associated with elevated levels of triglyceride?
    • Fredrickson Type I, IIb, IV, and V hyperlipoproteinemias
    • Pancreatitis
    • Alcoholism
    • Obesity
    • Hypothyroidism
    • Nephrotic syndrome
    • Storage diseases (Gaucher, Niemann-Pick)
  11. What test methodology is used to measure triglyceride?
    Enzymatic methodology
  12. What is the major protein found in HDL and activates lecithin-cholesterol acyltransferase (LCAT) and removes free cholesterol from extrahepatic issues?
    Apo A-1
  13. What is Apo A-1 considered?
    Antiatherogenic
  14. What is the major protein found in LDL and is associated with increased risk of coronary artery disease?
    Apo B-100
  15. What is an independent risk factor associated with impaired plasminogen activation and thus decrased fibrinolysis?
    Lp(a)
  16. What do high levels of Lp(a) suggest?
    Increased risk for coronary heart disease and stroke
  17. What test methodologies are used to measure Apo-A, Apo-B, and Lp(a)?
    • Immunoturbidimetric
    • Immunonephelometric
  18. What is the reference range of Apo-A?
    120-160 mg/dL
  19. What is the reference range of Apo-B?
    <120 mg/dL
  20. What is the reference range of Lp(a)?
    <30 mg/dL

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