Card Set Information
Quiz 7 questions
NSAIDS work at a molecular level by inhibiting the enzyme COX which stands for:
This (Cyclooxygenase) enzyme synthesizes the inflammatory molecules:
Celebrex was claimed to only inhibit the isozyme:
The most common adverse effect of this (Celebrex) family of drugs:
Mi & Strokes
The potent prescription NSAID that should not be used for more than 5 days:
The common OTC NSAID with a 6-8 hour half life:
A major advantage of Tylenol over the NSAIDs:
It does not cause gastric ulcers
A drug that is prescribed for rheumatoid arthritis as well as cancer:
An injectable drug that inhibits tumor necrosis factor that is used for a variety of auto-immune diseases:
Enbrel / Humira
The life threatening adverse effect from an opiate overdose:
A more potent opiate than morphine which has lower incidence of nausea:
About %7 of the American population do not get very good pain relief from codeine because:
They lack the metabolizing enzyme CYP 2D6
___ is a morphine derivative that was the most commonly prescribed drug in the country in 2005
It (Hydrocodone) is almost always combined with ____________
Another common derivative of morphine available in a long acting form that has become a popular street drug and was publicized by Rush Limbaugh
It (oxycontin) was reformulated in fall 2011 because:
people were crushing or chewing them to get a faster high
An opiate that is currently drug of choice for the pain associated with childbirth:
An antitussive with mild hallucinogenic properties:
___was originally developed as an alternative to heroin that did not require use of needles, but has been used increasingly as a pain medication in its own right which has a __ onset.
Methadone & slow
An opiate that is commonly prescribed for cancer patients and those with frequent vomiting:
The antidote for opioid overdose:
An opioid that is used for treating diarrhea:
There is very little likelihood of this drug (Imodium) being abused because :
it doesn't get absorbed out of the GI tract
A common local anesthetic in the dental office:
Cocaine causes major damage to the noses of people snorting regularly due to its ___ properties.
Tagamet, Pepcid and Axid are examples for the _____ family of drugs which are used to reduce the pain of uclers.
Histamine 2 Antagonists
The family name of the other major family of drugs used to reduce the pain of ulcers:
Proton Pump Inhibitors
All generic names of the above (Proton Pump Inhibitors) family end in:
A commonly prescribed PPI:
Prilosec / Nexium
The ARB family of antihypertensives have generic names that all end in :
Prior to 1970's most medical research was funded by____
What alternatives to an implated defibrillator are suggested by Dr. Abramson?
Diet and Exercise
How did the drug makers make sure that Nexium appeared more efficacious than Prilosec?
They gave twice the dosage of Nexium
In what way is the list of authors on a medical article sometimes misleading?
Medical articles can be written by ghostwriters who were not involved in the research process.
The most commonly prescribed drug in the ACE inhibitor family:
a common adverse effect to this family (ACE Inhibitor):
A related family (to ACE inhibitors) which does not have the above problem (cough) has the generic names that end in:
___ family of antiHTN commonly can cause edema.
Calcium Channel Blockers
An angina drug that is commonly taken sublingually:
The actual active molecule produced from Nitroglyceride:
Potassium sparing diuretics such as _____ work on the ____ portion of the kidney nephron.
Spirinolactone & last distal convoluted tubules
An anticoagulant from pig intestines that is given by injection:
An injection anticoagulant with more reproducible activity than the above drug:
An anticoagulant with a very short half life:
The activity of the anticoagulant ________ is measured with an INR number which stands for ______.
Warfarin & International Normalized Ratio
A patient with an INR= 1.2 is at risk of having __
Plavix is used to inhibit :
The naturally occurring enzyme which dissolves clots:
Name the most commonly prescribed generic statin:
Name the best selling statin drug still under patent:
The statin drugs can have adverse effects on:___ and _____
muscle tissue & liver organ
A drug which inhibits the absorption of dietary cholesterol:
Sales of the above drug dropped after a trail which showed that Zetia:
Did not reduce risk of MI and Stroke
A vitamin which lowers cholesterol when taken in megadoses:
NSAID stands for:
Non-Steroidal Anti-Inflammatory Drugs
Large doses of NSAIDs may cause _______ of renal arteries
NSAIDs are also often used to treat menstrual cramps, medically referred to as:
An OTC NSAID that advertises it lasts the "whole day" (8 hrs):
Golilocks has a total cholesterol of 200 mg/dL and LDL of 180 mg/dL. What is her total/HDL ratio? She is at ____ risk of MI or ischemic stroke.
10 (200/20=10) & high
Goldilocks goes on Vytorin and her lab results come with a total cholesterol = 160 mg/dL and her LDL= 120 mg/dL. Her total/HDL ratio is ____. She is now at ____ risk of MI or ischemic stroke.
4 & average