Quiz 6

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Quiz 6
2013-03-12 01:22:13
OIT pharm

Quiz 6
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  1. Two common diuretics and the location in the nephron where they act:
    • 1- hydrochlorothiazide - early distal convoluted tubule
    • 2- furosemide - ascending loop of Henley
  2. The most common adverse effect of both these diuretics is loss of ___ ions, resulting in _____.
    K+ & hypokalemia
  3. A clinical symptom of hyperkalemia is ____
    muscle cramps
  4. ACE stands for :
    Angiotensin Converting Enzyme
  5. Name the most common ACE inhibitor
  6. A common adverse effect of ACE inhibitors:
  7. The most commonly prescribed Ca channel blocker is:
  8. Two non-dihydropyridine Ca channel blockers that slow down heart rate as well as cause vasodilation:
    Verapamil & Diltiazem
  9. A family of drugs whose generic names end in -sartan:
    angiotension II receptor blockers
  10. An advantage of the above family (ARB) over ACE inhibitors:
    no cough
  11. A potassium sparing diuretic which is also used to decrease hair growth in trans gender females:
  12. A second potassium sparing diuretic besides Spironolactone:
    Triamterene or amiloride
  13. The potassium sparing diuretics work on the ____ portion of the kidney nephron and ___ effective diuretics by themselves.
    late distal convoluted tubule & are not
  14. ____ is a condition where a pregnant woman has a HTN crisis due to a reaction against her fetus
    Pre- Eclampsia
  15. An Anti-HTN drug that could be used with pre-eclampsia:
    labetalol, hydralazine
  16. An anti-HTN drug family whose generic names end in -pril:
    ACE inhibitors
  17. an anti-HTN family that commonly causes edema:
    Ca+ channel blockers
  18. ____ is a drug for angina that is rarely taken orally because it is rapidly metabolized in the liver. This rapid metabolism is called the ___ effect and is administered _____.
    Nitroglycerin & first-pass & sublingually
  19. Nitroglycerin reduces angina by causing primarily ____ vasodilation. This drug is metabolized into the actual drug ___
    venous & nitric oxide
  20. Another common drug that is metabolized into nitric oxide:
    isosorbide mononitrate (viagra)
  21. Two other drug families which are used to stop angina:
    Beta1 blockers & Ca+ channel blockers
  22. Give the name of an anticoagulant that:
    1- blocks vitamin K synthesis:
    2- must be given by injection:
    3- is a teratogen:
    warfarin & heparin & warfarin
  23. A partially purified anticoagulant whose clotting times are more reproducible:
  24. Oral anticoagulants measure clotting times with a 3 letter abbreviation:____ which stands for___________
    INR & International Normalized Ratio
  25. Names of two most commonly prescribed drugs in the "blockbuster" family that inhibits cholesterol synthesis:
    Simvastatin & Atorvastatin
  26. "Blockbuster" family can occasionally cause damage to two organs/tissues:
    Liver & muscle
  27. A drug reducing serum triglycerides:
  28. Tricor does not reduce risk of MIs and Strokes. The lowering of lipids in this case is a _____ outcome which does not produce the desired clinical outcome.
  29. A drug which lowers absorption dietary cholesterol:
  30. Zetia is commonly prescribed with a statin drug and sold as the combo drugs:
  31. What problem was the PDUFA act designed to correct>
    slow drug approval time
  32. How was the PDUFA mandate funded?
    Application fees
  33. Rezulin was prescribed to treat: