Clomipramine and Venlafaxine: blocks reuptake of 5-HT and NE.
Fluoxetine: blocks reuptake of 5-HT.
Buspirone: is a 5-HT1A receptor agonist.
Clomipramine; a tricyclic antidepressant.
-Alleviates anxiety and fear but with high dropout rate due to adverse side effects.
-Produces side effects: drowsiness, dry mouth, constipation, increased sweating, blurred vision, light-headedness, headache, dizziness, tremors.
Fluoxetine: a SSRI-type antidepressant.
–Alleviates anxiety and fear.
Venlafaxine: a bicyclic antidepressant.
–Alleviates anxiety and fear without producing sedation.
–Alleviates anxiety and fear without producing significant sedation and drowsiness and with gradual onset of anxiolytic effects.
–Does not produce amnesia and mental confusion.
–Does not potentiate the effects of alcohol, benzodiazepines, or other CNS sedatives.
–Exhibits little potential for addiction or abuse.