As effective as TCAs but do not cause the hypotension, sedation or anticholinergic effects of TCAs.
Produces CNS excitation vs TCA sedation.
Effects begin in 1-3 weeks.
Death from OD rare.
Causes sexual dysfunction in 70% of patients.
Weight gain common complaint.
- Abrupt discontinuation can cause withdrawl syndrome, dizziness, HA, neusea, sensory disturbances, tremor, anxiety, and dysphoria.
- Must taper down!
Produce selective inhibition of serotonin reuptake, intensifying transmission at serotonergic synapses.
May cause but rare: extrapyramidal effects, bruxism, and bleeding disorders, use with caution in Pt. with hx of GI bleed.
- Common SSRI's include:
- Prozac, Zoloft, Lexapro, Celexa, Luvox, Paxil