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Names / Class
Class III Potassium channel blocker
Mechanism of Action
- Decreased sinus automaticity
- Decreased speed of conduction
- Increased action potential of all cardiac tissues
- Increased refractory period of AV node
- Decreased peripheral vascular resistance
- Increased PR & QT intervals
- (alpha & beta adrenergic blockade)
- *Increases action potential to all cardiac tissue
- *Decreases sinus automaticity & speed of conduction
- *Decreases peripheral vascular resistance
Onset of Action
- 2 - 3 days (oral)
- 3 - 7 hours (oral)
- 40 - 55 days
- 1st line drug in cardiac arrest
- Stable iregular narrow-complex tachycardia (A-Fib)
- Stable narrow-complex tachycardia - to control rapid ventricular rate due to accessory pathway.
- Breastfeeding Pts in cardiogenic shock
- Severe sinus node dysfunction resulting in marked sinus bradycardia
- 2nd & 3rd degree heart block
- Symptomatic bradycardia
- Known hypersensitivity to med
Precautions / Side Effects
- Use with caution in latent or manifest heart failure
- Monitor EKG
- Increased ventricular beats
- prolonged PR interval, QRS complex, and QT interval
- May react with: Warfarin, Digoxin, Procainamide, Quandine, & Phenytoin.
- V-Fib or Pulseless V-Tach:
- 300 mg IV or IO over 10 minutes, repeated at 150 mg
- A-Fib: 150 mg IV or IO over 10 minutes, repeated as needed. Followed by: 1 mg/min over 6 hours, then 0.5 mg/min as needed.
- 5 mg/kg IV or IO over 30 minutes
- Repeat up to 2 additional doses, to a max of 15 mg/kg.
2.2 gm in 24 hours
Routes / How Supplied
IV or IO; infusion