Amiodarone HCL

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Author:
Ritameeker
ID:
206919
Filename:
Amiodarone HCL
Updated:
2013-03-12 21:57:05
Tags:
Amiodarone Cordarone Potassium channel blocker antiarrythmic paramedic study
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Description:
Amiodarone / Cordarone
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  1. Amiodarone

    Names / Class
    Cordarone

    Class III Potassium channel blocker
  2. Amiodarone

    Mechanism of Action
    • Decreased sinus automaticity
    • Decreased speed of conduction
    • Increased action potential of all cardiac tissues
    • Increased refractory period of AV node
    • Decreased peripheral vascular resistance
    • Increased PR & QT intervals
    • (alpha & beta adrenergic blockade)
    • *Increases action potential to all cardiac tissue
    • *Decreases sinus automaticity & speed of conduction
    • *Decreases peripheral vascular resistance
  3. Amiodarone

    Onset of Action
    Peak Effect
    Duration
    Half-Life
    • 2 - 3 days (oral)
    • 3 - 7 hours (oral)
    • Varies
    • 40 - 55 days
  4. Amiodarone

    Indications
    • V-Tach
    • V-Fib
    • 1st line drug in cardiac arrest
    • Stable iregular narrow-complex tachycardia (A-Fib)
    • Stable narrow-complex tachycardia - to control rapid ventricular rate due to accessory pathway.
  5. Amiodarone

    Contraindications
    • Breastfeeding Pts in cardiogenic shock
    • Severe sinus node dysfunction resulting in marked sinus bradycardia
    • 2nd & 3rd degree heart block
    • Symptomatic bradycardia
    • Known hypersensitivity to med
  6. Amiodarone

    Precautions / Side Effects
    • Use with caution in latent or manifest heart failure
    • Monitor EKG
    • Hypotension
    • Bradycardia
    • Increased ventricular beats
    • prolonged PR interval, QRS complex, and QT interval
    • Dyspnea
    • Cough
    • May react with: Warfarin, Digoxin, Procainamide, Quandine, & Phenytoin.
  7. Amiodarone

    Adult Dose
    • V-Fib or Pulseless V-Tach:
    • 300 mg IV or IO over 10 minutes, repeated at 150 mg
    • A-Fib: 150 mg IV or IO over 10 minutes, repeated as needed.  Followed by: 1 mg/min over 6 hours, then 0.5 mg/min as needed.
  8. Amiodarone

    Pedi Dose
    • 5 mg/kg IV or IO over 30 minutes
    • Repeat up to 2 additional doses, to a max of 15 mg/kg.
  9. Amiodarone

    Max Dose
    2.2 gm in 24 hours
  10. Amiodarone

    Routes / How Supplied
    IV or IO; infusion

    Vial

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