Karpatkin spring 5

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Author:
shmvii
ID:
207080
Filename:
Karpatkin spring 5
Updated:
2013-05-13 21:20:35
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karpatkin
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spring 2013
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  1. first off, I need you to know I'm just putting in the blind memory elements of this lecture and hoping HK's technique of comprehension over memorization works
    inshallah

    so you have to read the Parkinson handout when studying
  2. Schwab & England Activities of Daily Living Scale - format, basics
    rates pt at 100, 80, 60, 40, 20, or 0% independance
  3. Hoehn & Yahr Stages of PD
    • breaks pt into stages 1, 1.5, 2, 2.5, 3, 4, 5
    • and then those into mild (1-2), mod (2.5-4) severe (5)
    • basically mild is unilat, mod is bilat, and severe is bed-bound
  4. what's sinemet?
    • carbidopa w levadopa
    • the carbidopa helps the levadopa enter the brain w fewer side effects than if it was just levadopa
  5. trade and sci names of the 4 dopamine agonists
    • parlodel (bromocriptine)
    • requip (ropinirole)
    • apokyn (apomorphine)
    • mirapex (pramipexole)
  6. 2 COMT inhibitors trade names (sci names)
    • Comtan (entacapone)
    • Tasmar (tolcapone)

    thse inhibit the action of catechol-O-methyl transferase, which is involved in breaking down dopamine
  7. name of the drug that's a combo of levodopa, the drug that makes levodopa go better, and one of the COMT inhibitors
    Stalevo-A = levodopa + carbidopa + entacopone (comtan)
  8. 2 MAO-B inhibitors trade names (sci names)
    • they protect dopamine (and the cells that make dopamine??) from breakdown
    • azilect (rasagiline)
    • eldepryl/ zelapar (selgiline)
  9. anticholinergics - 3 names - trad & (sci)
    • artane (trihexyphenidyl
    • cogentin (benztropine mesylate)
    • (ethopropazine)
  10. where should you do deep brain stim if  you want to treat essential tremmor & medically refractory parkinson's tremor
    ventral intermediate nucleus (VIM) of thalamus
  11. where should you do deep brain stim if  you want to treat PD
    globus pallidus interna (GPI) or subthalamic nucleus (STN)
  12. where should you do deep brain stim if  you want to treat primary dystonia
    globus pallidus interna or subthalamic nucleus

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