"Mannitol (Osmitrol) is a osmotic diuretic. Its use is contraindicated in patients with a hypersensitivity to it as well as in those with anuria, severe dehydration, pulmonary congestion, or cerebral hemorrhage. Treatment should be terminated if severe cardiac or renal impairment develops after the initiation of therapy. It is available only in parenteral form as 5%, 10%, 15%, 20%, and 25% solutions for intravenous injection. Mannitol may crystallize when exposed to low temperatures. This is more likely to occur when concentrations exceed 15%. Because of this, mannitol should always be administered intravenously through a filter, and vials of the drug are often stored in a warmer in the pharmacy. Before administering mannitol, the nurse should visually inspect the mannitol container for precipitants. Pregnancy category C."