45-46

Card Set Information

Author:
neotinky
ID:
2075
Filename:
45-46
Updated:
2009-12-01 22:31:55
Tags:
protein synthesis antibiotic
Folders:

Description:
antibiotics and protein synthesis
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  1. Puromycin
    • premature chain termination
    • Euk, Prok

    No clinical use/ cause premature chain termination due to low affinity to the P site
  2. tetracyclins
    both euk and prokaryotes (but selectively concentrated in bacteria)

    prevent aminoacyl-tRNA from binding to A site ( elongation?)
  3. streptomycin
    • initiation (prevent fmet tRNAf binding to the P site) , misreading of mRNA
    • prokaryote
  4. chloramphenicol
    • peptidyl transferase (elongation)
    • prokaryotes
  5. cycloheximide
    • peptidyl transferase (elongation)
    • eukaryotes
  6. erythromycin
    • blocks translocation
    • prokaryotes

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