genetics

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drosophila are model system b/c:
- simple structure
- powerful genetics
- gene conservation
fluorescence in-situ hybridization (FISH)

screening for tissue specific expressed genes

-step 1 in research strategy
RNA interference

knocking out specific genes suspected of having key roles in development

step 2 in research strategy
null mutants

DNA level, remove piece of DNA generates mutant

step 3 in research strategy
phenotypic analysis

apical membrane, luman formation, apical cytoskeleton, cytoskeleton-membrane linkage, apical secretion signaling pathways

step 4 in research strategy