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Plavix
Names / Class
Clopidogrel
Platelet Aggregation Inhibitor
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Plavix
Mechanism of Action
Inhibits platelet aggregation by selectively binding to the ADP receptors on the surface of platelets & binding fibrogen to the GP IIb-IIIa receptor on activated platelets.
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Plavix
Onset of Action
Peak Effects
Duration
Half-Life
- 2 hours
- 3 - 7 days
- 7 - 10 days
- 7 - 8 days
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Plavix
Indications
- Acute coronary syndrom
- Recent MI
- Stroke
- Peripheral Vascular Disease (PVD)
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Plavix
Contraindications
- Hypersensitivity to the drug
- Hemostatic disorder
- Active pathological bleeding (peptic ulcer, or intracranial bleeding)
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Plavix
Precautions
Pts taking NSAIDs (nonsteroidal anti-inflammatory)
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Plavix
Side Effects
- Increased risk of bleeding
- Fever
- Allergic reactions
- Myalgias
- Arthralgias
- Bronchospasm
- Skin rash
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Plavix
Adult Dose
- Acute Coronary Syndrome & Non ST elevation ACS:
- 300 mg loading dose, followed by 75 mg once daily in combination with Aspirin.
- STEMI:
- 75 mg once daily in combination with Aspirin (with or without a loading dose, and with or without thrombolytics)
- Recent MI, Stroke, or PAD:
- 75 mg once daily.
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Plavix
Pedi Dose
Not Indicated
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Plavix
Max Dose
- 75 mg daily
- (300 mg - loading dose)
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Plavix
Routes / How Supplied
PO
Unknown
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