Plavix

Clopidogrel

Platelet Aggregation Inhibitor

Inhibits platelet aggregation by selectively binding to the ADP receptors on the surface of platelets & binding fibrogen to the GP IIb-IIIa receptor on activated platelets.

• 2 hours
• 3 - 7 days
• 7 - 10 days
• 7 - 8 days

• Acute coronary syndrom
• Recent MI
• Stroke
• Peripheral Vascular Disease (PVD)

• Hypersensitivity to the drug
• Hemostatic disorder
• Active pathological bleeding (peptic ulcer, or intracranial bleeding)

Pts taking NSAIDs (nonsteroidal anti-inflammatory)

• Increased risk of bleeding
• Fever
• Allergic reactions
• Myalgias
• Arthralgias
• Bronchospasm
• Skin rash

• Acute Coronary Syndrome & Non ST elevation ACS:
• 300 mg loading dose, followed by 75 mg once daily in combination with Aspirin.
• STEMI:
• 75 mg once daily in combination with Aspirin (with or without a loading dose, and with or without thrombolytics)
• Recent MI, Stroke, or PAD:
• 75 mg once daily.

Not Indicated

• 75 mg daily
• (300 mg - loading dose)

PO

Unknown