OSD6 quick study

Smoking decreases risk

Pathergy test

Crops of mouth ulcers, genital ulcers, eye inflammation

STDs/Chlamydia

Hemorrhagic crusting of vermillion borders of the lips

Bulls eye skin lesions

Steven's Johnson syndrome

Dekeratinization and desquamation of filiform papillae

Ageusia, Dysgeusia, lichenoid reaction, epithelial sloughing

Labial enlargement and facial swelling

Strawberry gingivitis

Subepithelial split at BM, IgG and C3

Abs against collagen VII

IgA Abs

DSG3

Tzanck cells

Fishnet appearance on IF

Patient already diagnosed with cancer

DSG1, subcorneal split

Wickham's Striae

Hyperkeratotic , leukoplakic, raised or flat on tongue and buccal mucosa

Looks like MMP, but has white striae and is precancerous

Large bullae rupture and cause erosion

Erosions and white striae around amalgam

LP invades the nerve

Band of T lymphocytes around BM, thickening of BM, degeneration of basal cells, antifibrinogen Ab

Topical tx that is not a steroid (good for DM and HTN pts)

Malar rash, photosensitivity

ANA+, dsDNA+, anti-smith Abs

Brown tumor

Vitamin D deficiency in children

Vitamin D deficiency in adults

Increased osteoid, decreased mature bone

Deficiency of bone tissue per unit volume of bone, treat with bisphosphonates

Giantism and acromegaly

"hair on end"-- radial striations in the diploic space of the skull

Bilateral uncontrolled growth of bone w/ cement lines

Bilateral uncontrolled growth of bone w/ cement lines

Sclerodactyly, widening of PDL space, Reynaud's syndrome

Enlarged Langerhan's cells, eosinophils and "floating teeth"

Acute Disseminated LCH

Bone lesions, diabetes insipidus and exophthalmos Hand-Schuller-Christiansen Triad=

PTCH mutation

Multiple OKCs and basal cell carcinomas

variation in allelic expression when the allele is penetrant.

frequency of expression of an allele when it is present in the genotype of the organism

RET mutation

Marfanoid body build
oral mucosal neuromas
medullary carincoma of the thyroid pheochromocytoma

APC mutation

Multiple osteomas, impacted teeth, odontomas, 100% develop colorectal carcinoma, supernumary teeth

STK11 mutation

Benign (hamartomatous) polyps,
freckle-like spots on perioral skin and hands)

NF1 mutation

Café au lait spots
crowe's sign(axillary freckling)
lisch nodules (iris)
multiple neurofibromas

Port wine stains along CN V
leptomeningeal angiomas

touch nose w/ tongue

Hypermobility of joints, elastic skin, gorlin sign

multiple vessel abnormalities->exessive bleeding
multiple papules
recurrent epistaxis
telangiectasias
AV malformations

Red papules, family hx, epistaxis, AV-malformation Hereditary hemorrhagic Telangiectasias,Peg-shaped incisors, heat intolerance (can't sweat)

RUNX2 (CBFA1) mutation

Hypoplastic clavicle, delayed eruption of permanent teeth

Café au lait spots, sexual precocity, fibrous dysplasia

Fe deficiency + glossitis + dysphagia (esophageal webs)

Facial paralysis, swollen lips (OFG), fissured tongue

Esophageal webs

Erosion, osteophytes, subchondral sclerosis

Inherited skin condition with no other allergic conditions

Scratching leads to excoriations

Itchy skin rash→ begins hours after contact

Excessive contact with irritatnts, causes hand dermatitis

Increased skin cell turnover with slow shedding

Auspitz's sign

Histamine causes angioedema of lips and hands

Abnormal C1NH protein

Tongue blade test Physical urticaria

P. Acnes

Affects areas exposed to sunlight over a long period of time, solar elastosis also involved

Migraine headaches, sun damage, erythema, telangiectasia

Mixed population of staph and strep

Collection of pus in a firm mass caused by S. aureous

Survive in dead keratin

Athlete's foot

Jock itch

Ringworm

Ringworm of the scalp

Burrow into skin

Do NOT burrow, transmitted by combs

Larvae enter swimmer's pores and die

Increased epithelial turnover rate

Hair loss from crash diets

Abrupt hair loss from chemo

Patchy hair loss from autoimmune condition

Jellyfish and coral stinging structures

Antimicrobial anti-HIV components of saliva

Dark pink submucosal swelling

Normal low PMN counts

Absence of PMNs, caused by anticancer chemotherapeutic agents

Periodic reduction in PMN population

Decreased production, increased destruction, sequestration in spleen

Increase in mass of RBCs→TIA, CVA, MI

Scooped out mandible, floating teeth, large langerhan's cells

Blast transformation, 9/22 translocation

Reed-sternberg cells

Owl-eye nucleus

B-lymphocytes affected, MALT formation

Cells have minimal cytoplasm

"starry sky" appearance

Kids, posterior jaws, multiple quadrants affected

B-lymphocyte malignancy associated with EBV

Bence-Jones protein, amyloid deposition

Eccentric nuclei, stippled nuclear chromatin

Plasma cell origin, Punched out lesions on radiograph

Glossitis, angular cheilitis, koilonychias, splenomegaly

VIII-A and IX-B deficiency

Impaired collagen synthesis results in bleeding gums

White, creamy, removable plaques

Elongated hyphae, thigmotropism

Diagnosed using periodic acid Schiff

Treated with Amphotericin B

Leads to CNS involvement

Cough, anemia, shiny papules, 3rd most common

Reactivation of latent infection, fever, weight loss

Causes sinus infection and invasive lesions

Viscera, lymph nodes, mucocutanous tissues affected

Pulmonary infection and erythema multiforme

Erythematous linear banding, not related to plaque

Destruction of one or more interdental papillae

Loss of periodontal attachment and bone

Ulcers on non-keratinized mucosa

Ulcers on keratinized mucosa

In HIV, will cross onto the "wet" lip

Stops at midline along one dermatome

NO langerhan's cells, chromatin margination, EBV

HPV-related lesions Verruca vulgaris, condyloma acuminatum, focal epithelial hyperplasia HHV-8, cancer of lymphatic endothelium and forms bloodfilled vascular channels

HIV increases risk by 60x

HIV-related salivary gland disease Sjogren-like syndrome, diffuse CD8 lymphocytic infiltration (DILS), lymphoepithelial cysts of salivary glands, malignant lymphoma Improving immune system reduces Tregs and worsens clinical symptoms

large, bulbous, ruddy nose caused by granulomatous infiltration, commonly due to untreated rosacea