MIC 541- Lecture 19

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kyleannkelsey
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208073
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MIC 541- Lecture 19
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2013-03-18 18:19:50
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Mic 541 Lecture 19 Creighton Pharmacy
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Mic 541- Lecture 19, Creighton Pharmacy
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  1. What is woolsorter’s disease?
    Cutaneous Anthrax
  2. What is characteristic of inhalational anthrax?
    Mediastinal Widening
  3. What is the appropriate treatment for an adult with inhalational anthrax?
    • Ciprofloxacin 400mg q12h
    • Doxycycline 100mg q12h
  4.  4 Anaerobic Gram + Bacilli
    • Clostridium botulinum
    • Clostridium perfringens
    • Clostridium tetani
    • Clostridium difficile
  5. Clostridium botulism causes:
    • classical botulism
    • wound botulism/infant botulism
  6. Clostridium perfringens causes:
    • gas gangrene
    • food poisoning
    • uterine infection
  7. Anaerobic Gram + Bacilli Characteristics:
    • Spore formers
    • Obligate anaerobes
    • Produce a large # of enzymes and toxins that are medically important
    • Rods
    • Ubiquitous/soil & intestinal tracts of man and animals
  8. Meatbolism of Anaerobic Gram + Bacilli
    Obligate anaerobes
  9. Spore formation in Anaerobic Gram + Bacilli
    Are spore formers
  10. Medical signifcance of Anaerobic Gram + Bacilli
    Produce enzymes and toxins
  11. Morphology of Anaerobic Gram + Bacilli
    rods
  12. Anaerobic Gram + Bacilli are found:
    Ubiquitous in soil and intestines
  13. Clostridium botulinum is and infectious disease (True/False)
    False
  14. Clostridium Botulinum is associated with
    Improperly canned or dried food
  15. Clostridium Botulinum causes disease by:
    injestion of preformed toxin
  16. Clostridium botulinum produces how many neurotoxins?
    8
  17. While immunologically distict Clostridium Botulinum neurotoxins are found in humans?
    A,B, E
  18. Clostridium Botulinum toxins are absorbed via:
    intestine
  19. Clostridium Botulinum toxins inhibit:
    Acetylcholine release
  20. Latenet action period of Botulism toxin is
    24 to 72 hours
  21. Botulism causes:
    Flaccid paralysis
  22. Syptoms of C. botulinum are:
    • Double vision
    • dizzy
    • weakness
    • difficulty swallowing/speech
    • respiratory failure/death
  23. Diagnosis of Botulsim
    • patient serum/animal tests
    • look for G+ spore formers
  24. Describe Clostridium Botulinum
    G+ rods, spore forming, spore forms at end of rod
  25. Woman parylized by carrot juice imbibed:
    C. Botulinum
  26. Action of botulism
    blocks acetylcholine release into neural synapse and prevents contraction
  27. Medical Uses of Botox/Face:
    Prevents blepharospasm and strabismus (eye musclespasms)

    Stifle migranes
  28. Spinal Botox uses:
    Treatment for Cervical dystonia – neck pain, neck stiffness
  29. Urogenital uses for botox:
    Treat leakage of urine (incontinence) in    adults with overactive bladder
  30. Periphreal Botox uses:
    Treat increased muscle stiffness in elbow,    wrist, and finger muscles
  31. C. Botulinum Pharmaceutical treatment:
    trivalent antisera = A, B, E
  32. C. Botulinum treatment non-pharma
    intensive respiratory care/pressure chamber
  33. C. Botulinum Prevenetion
    heat home canned/dried foods for 10 minutes at 100o  C = inactivates toxin
  34. Clostridium perfringens causes
    • Gas Gangrene
    • Food Poisoning
    • Uterine Infection
  35. Gas Gangrene Symptoms:
    • local pain
    • swelling
    • gas
    • necrotic tissue
  36. Diagnosis of Gas Gangrene
    G+spore formers/culture
  37. Treatment of Gas Gangrene
    excise teh tissue and hyperbaric oxygen
  38. Gas Gangrene organism multiplies in the
    wound tissue
  39. C. perfungins Food poisoning happens when:
    Injest large number of organisms and spores form
  40. C. perfungins food poisoning syptoms:
    Violent diarrhea and cramps
  41. C. perfungins uterine infection % female carriers
    5%
  42. C. perfunigins uterine infection can cause:
    • prolonged labor
    • septic abortion
    • high fever
    • necrosis
  43. C. perfungins treatment:
    Surgical removal
  44. Clostridium tetani infections are associated with:
    accident, gunshot, knife, pierced ears
  45. Clostridium tetani number of toxins produced
    1 serotype
  46. Clostridium tetani causes:
    • spastic paralysis in the central nervous sytsem
    • can lead to respiratory collapse
  47. Clostridium Tetani diagnosis:
    clinicalgrounds/isolate/animals
  48. Clostridium Tetani treatment:
    antiserum,clean wound
  49. Tetanus patient stance description:
    Arched back
  50. Tetanus in infnts can be seen at:
    Umbellical stump
  51. Clostridium Difficile is associated with
    antibiotics and bowel disruption
  52. C. Difficile toxin causes
    • pseudomembranous colitis
    • peritonitis
    • perforation of bowel wall
  53. Risk factor for Clostridium Difficile
    40% is clinical
  54. Diagnosis of Clostridium Difficile
    • tox in feces
    • proctoscope
  55. Morphology of Pseudomembranous Colitis
    • White plaques of fibrin, mucus, and inflammatory cells overlying the normal mucosa
    • Raised yellow plaques 2-10 mm in diameter

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