Lecture 17: Organs of the mesoderm II

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a_bobic6
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208494
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Lecture 17: Organs of the mesoderm II
Updated:
2013-03-20 13:48:07
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biology
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limb formation limb patterning
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  1. What does LPM(Lateral plate mesoderm) give rise to?
    somatic mesoderm
  2. What does somatic mesoderm give rise to?
    limb bud
  3. What does somatic mesoderm make?
    limb buds
  4. What induces limb bud outgrowth?
    fgf10
  5. When doing an experiment how is fgf10 transferred?
    Using a bead of recombinant fgf10
  6. Which genes specify fore and hindlimb fate?
    Tbx4 and Tbx5. they are transcription factors
  7. The forelimb is which appendage?
    anterior
  8. The hindlimb is which appendage?
    posterior
  9. Which tbx gene is expressed in the hindlimb?
    tbx4
  10. Which tax gene is expressed in the forelimb?
    tbx5
  11. How is proximal/Distal patterned?
    The longer AER(apical ectodermal ridge) is the  longer the limb bud grows
  12. What does AER produce?
    fgf8
  13. Where is AER?
    Distal tip of limb bud
  14. What regulates Dorsal/Ventral patterning of limb bud?
    epidermis
  15. What is expressed in the dorsal epidermis?
    Wnt7a
  16. what does Wnt in the dorsal epidermis induce?
    Lmx1(meso)
  17. What is expressed in the ventral epidermis?
    En1
  18. What does En1 in the ventral epidermis inhibit?
    Wnt 7a
  19. How is anterior/posterior axis patterned?
    -ZPA(zone of polarizing activity) secures shh (morphogen) in the posterior region
  20. What is necessary to polarize the limb bud?
    shh

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