Hemoglobinopathies and Thalassemias

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Author:
narine010
ID:
208504
Filename:
Hemoglobinopathies and Thalassemias
Updated:
2013-03-20 09:20:44
Tags:
Hematology
Folders:

Description:
hemolytic anemias
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  1. Hgb composition?
    • A (2 alpha, 2 gamma) 95-97%
    • A2 (2 alpha, 2 sigma) 2-3%
    • F (2 alpha, 2 gamma) 1-2%
  2. What is Hgb S?
    • Sickle cell anemia
    • valine substituted for glutamic acid at position 6
  3. What is Sickle Cell crisis?
    • Sudden weakness
    • rapid pluse
    • faintness
    • pallor of lips and mucous membrane
    • enlarged spleen
  4. Laboratory Findings for Sickle Cell
    • low Hbg, Hct, RBC
    • RBC indices; normochromic, normocytic
    • increased reticulocyte
    • bone marrow hyperplasia
  5. Sickle Cell trait?
    usually present with hemolytic anemia except crisis
  6. Hgb C
    • lysine replace glutamic acid
    • forms crystals

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