MIC 541-Lecture 22
Card Set Information
MIC 541-Lecture 22
MIC 541 Lecture 22 Creighton Pharmacy
MIC 541-Lecture 22, Creighton Pharmacy
Rickettsia family obligate intracellular genera
Rickettsia that is not an intracellular pathogen
Motility in Rickettsia
Shape of Rickettsia
Infect humans through what vectors?
arthropods: lice, fleas, ticks, mites
Most Rickettsia grow only under what conditions?
Intracellularly (though not viruses)
Rickettsia resemble what other organism?
What type of organism carries Rickettis and transefers it to Humans?
Arthropods (lice, fleas, mites and ticks)
Most Ricketssia re similar in size and shape (T/F)?
Most Rickettsia produce...?
Pathogenisis of Rickettsia begins with the transfer of organism to humans via:
After Rickettsia are transferred to humans through an arthropod bite, the next step is to:
Invade vascular endothelial cells
Once inside an endothelial cell, Rickettsia:
Destroy the cell
After Rickettsia destory the endothelial cell that they have invaded:
Inflammatory cells accumulate and blood leakage combine to create a rash.
After Rickettsia has formed a rash, the last step in their pathogenisis is to:
release organism from cell and spread to infect other cells
The basic steps of Rickettsia pathogenisis are:
Invade vascular endothelial cells
inflammatory cells accumulate and blood leaks =rash
Released organism infect and spread
Sigsn of Rickettsia Infection:
Fever and chills
4-6th day skin rash develops and persists through infection
: Q-fever = no rash (caused by Coxiella burnetii)
Rash does not occur when a patient has what Rickettsia infection?
Q-fever by Coxiella burnetii
The rash appears on what day of the Rickettsia infection?
Sever Headach is one of the symptoms of Rickettsi infection (T/F)?
Typhus group of Rickettsial Diseases includes what disease?
Epidemic Typhus is caused by what Rickettsia
What are the symptoms of a Rickettsia prowazekki infection?
skin rash (trunk to extremities)
Rickettsia prowazekii causes what disease?
Epidemic Typhus is usually spread by
body louse (bite and feces)
Rickettsia prowazekii is transferred to humans via:
body louse (bites and feces)
A skin rash of Rickettsia prowazekii is on what body part?
trunk to extremities
Epidemic typhus has a rash that is located where?
trunk to extremities
The spotted fever group of Rickettsia includes:
Rickettsia rickettsii is also known as
Rocky mountain spotted fever
Rocky mountain spotted fever is transferred by
Rickettsia rickettsii causes a rash where?
and soles of feet
Rocky mountain spotted fever symptoms are:
Rash on wrists and ankles
A skin rash on the writs that may extend to palms or onthe ankles and may extend to teh soles of feet and trunk is fom what Rickettsia and Disease?
Rickettsia rickettsii, Rocky mountain stopped fever
Rickettis can be stained with
Gimenez stain colors Rickettsia what?
Larvae and lymphs of Rocky mountain wood tick feed on what?
The lifecycle of a Rocky mountain wood tick is:
Rocky mountain wood tick is found where?
Rocky mountain states and in southwestern Canada
Adult ticks feed on what?
Only the Rocky mountain wood tick can carry R. rickettsia (T/F)
False, others have been shown to also carry it, but play a more minor role
The Scrub typhus group includes:
Orienta tsutsugamushi causes:
Scrub typhus is caused by:
Orienta tsutsugamushi is transferred via:
A mite bite
The symptoms of an Orienta tsusugamushi infection are:
Eschar skin rash that cover body
The Q fever group includes:
Coxiella burnetii causes:
Coxiella Burnetii is transferred via
Coxiella burnetii can resist dessication outside of host for:
Up to 3 years
Sypmtoms of Q fever are
NO SKIN RASH
All other diseases of Rickettsia cause a rash except:
Coxiella burnetii's Q fever
Trench fever group has been transferred to:
Trench fever group includes:
Rochalimaea quintana causes:
Rochalimaea quintana is transferred via:
body louse bite and feces
Trench fever is transferred via:
Body louse bite and feces
Trench fever symptoms are:
skin rash (global)
Early stages of Rickettsia infections show a rise in serum antibodies (T/F)?
Diagnosis of Rickettsi infections can be performed by what three main assays?
Cross reacting Proteus antigens
MIF or Microimmunoflourescence assay detects Rickettsia by:
detetcing antibodies directed against a specific outer membrane protein
PCR is a good way to detect Rickettsia (T/F)?
False, it is not well developed
Which detection method for Rickettsia is an agglutination reaction?
Cross-reacting Proteus antigens
Which Rickettsi detetction assay uses outer membrane proteins to detect serum antibodies of Rickettsia?
MIF or Microimmunoflourescence
Which Rickettsi disease has a vaccine under study?
Prevention fo Rickettsia can be performed by:
Using insectisides and cleaning
Q fever has a vaccine currently available?
no but there is one being tested
Pharmaceutical treatment of Rickettsia includes:
doxycycline and chloramphenicol
Chloramphenicol is the best choice drug for a Rickettsia infection (T/F)?
False, it has a greater change of relapse
Teh first line drug for Rickettsia infections is:
Ehrlichia invades what types of cells?
white cells (lymphocytes neutrophils and monocytes)
Whrlickia reservoirs other than human are:
ticks, deer and dogs
ticks transfer Ehrlichia to what mammals:
Himans, deer and dogs
What percent of patient show a rash when infected with Ehrlichia?
Most patients have a rash when infected with Ehrlichia (T/F)?
False, only 20%
Symptoms of Ehrlichia are:
Lymph node enlarged
Myalgia is a symptom of Ehrlichia (T/F)?
Ehrlichia is treatmed with:
Chlamydia is related to bacteria by:
DNA and RNA presence
Binary fission division
G- like cell wall
susceptible to antibiotics
Chlamydia has a cell wall much like a G - (T/F)?
Chlamydia divide by what process?
Chlamydia contain only RNA (T/F)?
False, they contain both DNA and RNA
Chlamydia is divided into how many groups?
The three groups of Chlamydia are:
Chlamydia trachomatis (group A)
Chlamydophila psittaci (group B)
Chlamydophila pneumoniae (group C)
Chlaymydia group c includes:
Chlamydophila psittaci is in which Chlamydia group
Grou A Chlamydia includes:
The development cycle of Chlamydia is:
Cell engulfs Elementary body
Elementary body enlarges in the cell to become reticulate body
Cell ruptures and releases elementary bodies
Trachoma is limited to what mammals?
Trachoma is found in many animals (T/F)?
False, only humans
Trachoma infects what cells?
epithelial cells of the eye
Trachoma is a Chlamydia disease in which group?
The greatest single cause of blindness is:
Trachoma is prominent in areas of:
The onset of Trachoma is slow (T/F)
False, it is abrupt
Symptoms of Trachoma are:
lymphocytes accumulate to form follicles
Blindnes of Trachoma is caused by:
lymphocytes accumulating to form follicles in the eye
Group A Chlamydia diseases include:
Lymphogranuloma venereum (LGV)
Non-gonococcal urethritis (NGU)
Diagnosis of Trachoma is performed by:
Isolate organism form conjunctiva
test eye secretions for trachoma antibodies
Inclusion conjunctivitis is in what Chlamydia group?
Inclusion Conjuctivitis causes disease in what two groups?
infants and adults
Inclusion Conjunctivitis causes blindness (T/F)
False, it resolves itself in a few months
How long does it take to resolve Inclusion conjunctivitis?
a few months
Inclusion conjunctivitis does not cause scarring (T/F)?
True, there is no scarring or blindess
Inclusion Conjunctivitis can cause a false positive in what other type of diagnostic test?
PAPS smears can be positive die to what non-related disease?
Lymphogranuloma venereum (LGV) isassociated with what behavior:
LGV stands for:
Symptoms of Lymphogranuloma venereum are:
vesicles on the genitals at 7-10 days after infection
vesciles soon rupture w/o scarring
2-8 weeks later a regional lymph nodes swell
Genital skin swells
At what point after Lymphgranuloma venereum infection do vesicles appear on teh skin?
At what point in a Lymphogranuloma venereum infection do the lymph nodes swell?
Non-gonococcal urtheritis usually causes problemes in what infection group?
Men, women rarely have problems
Non-gonococcal urethritis is caused by:
Non-gonococcal urtheritis can cause what risk to newborns?
PID and pneumonia
True ot False, Non-gonococcal urtheritis is chronic?
False, it is self limiting
The most prevalent bacterial STD is:
What percent are carriers for Chlaymydiosis in the reproductive tract?
Diagnosis of Chlamydiosis is by:
PCR or Immunoflourescent probe (culture costs time)
Chlamydiosis is treated by:
tetracyclines or arithromycin
Omaha is in region what based on Chlamydia ranking?
Chlamydia is increasing or decreasing in percent positive tests?
Increasing steadily from 1996 to 09
Clamydia rates are higher in men than women (T/F)?
False, men have alower rate of infection
The rate of Chlamydia infections are increasing in both men and women (T/F)?
True, though men have a lower incidence, they are increasing at the same rate
Thelowest states for Chlamydia infections are:
Idaho, Utah, Minnisota, West virginia and Vermont, Maine, Massachusets and New Hampshire
The area of the highest Chlamydia infection rates are:
Southe, Spotty midwest, New York, Arizona and Colorado and Texas, Alaska
The age range of most Chlamydia infections is:
15-24 and slightly less in the 25-29 population
Group B Chlamydia diseases include:
Psittacosis resivoir is:
Parrots (and other birds)
Symptoms of Psittacosis:
Eye and nostril
Psittacosis is passed to humans via:
Atypical pneumonia caused by Chlamydia Group B has what symptoms?
Asymptomatic for most cases
Chills, fever, headache and persistant cough in some
Treatment of Atypical pneumonia is by:
Turkey flocks tend to harbour what Chlamydia disease?
Group B Clamydophila psittaci causing Atypical pneumonia
Pneumonia from Chlamydia is caused by what group and species?
Group C, Chlamydophila pneumoniae
Taiwan Acute Respiratory Strain (TWAR) is caused by:
Clamydophila pneumoniae is transferred via:
person to person contact
Symptoms of Chlamydophila pneumoniae infection are:
Chlamydophila pneumoniae has a fest recovery (T/F)?
False, it has a slow recovery
Chlamydophila pneumonia infections are usually severe (T/F)?
False, they are usually mild
Diagnosis of Chlamydophila pneumoniae is by:
What are elementary bodies?
non-replicating infectious particle that is released when infected cells rupture
What are Orientia?
Orientia is a genus of bacteria in family Rickettsiaceae
What disease is caused by Coxiella burnetii?
What are the known rickettsial agents?