MIC 541-Lecture 22

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MIC 541-Lecture 22
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2013-03-22 13:53:59
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MIC 541 Lecture 22 Creighton Pharmacy
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MIC 541-Lecture 22, Creighton Pharmacy
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  1. Rickettsia family obligate intracellular genera
    • Rickettsia
    • Coxiella
    • Ehrlichia
    • Orientia
  2. Rickettsia that is not an intracellular pathogen
    Rochalimaea
  3. Motility in Rickettsia
    non-motile
  4. Shape of Rickettsia
    coccobacilli
  5. Infect humans through what vectors?
    arthropods: lice, fleas, ticks, mites
  6. Most Rickettsia grow only under what conditions?
    Intracellularly (though not viruses)
  7. Rickettsia resemble what other organism?
    Bacteria
  8. What type of organism carries Rickettis and transefers it to Humans?
    Arthropods (lice, fleas, mites and ticks)
  9. Most Ricketssia re similar in size and shape (T/F)?
    True
  10. Most Rickettsia produce...?
    Agglutinating antibody
  11. Pathogenisis of Rickettsia begins with the transfer of organism to humans via:
    Arthropod bite
  12. After Rickettsia are transferred to humans through an arthropod bite, the next step is to:
    Invade vascular endothelial cells
  13. Once inside an endothelial cell, Rickettsia:
    Destroy the cell
  14. After Rickettsia destory the endothelial cell that they have invaded:
    Inflammatory cells accumulate and blood leakage combine to create a rash.
  15. After Rickettsia has formed a rash, the last step in their pathogenisis is to:
    release organism from cell and spread to infect other cells
  16. The basic steps of Rickettsia pathogenisis are:
    • Arthropod bite
    • Invade vascular endothelial cells
    • destroy cell
    • inflammatory cells accumulate and blood leaks =rash
    • Released organism infect and spread
  17. Sigsn of Rickettsia Infection:
    • Fever and chills
    • Sever headache
    • 4-6th day skin rash develops and persists through infection
    • EXCEPTION: Q-fever = no rash (caused by Coxiella burnetii)
  18. Rash does not occur when a patient has what Rickettsia infection?
    Q-fever by Coxiella burnetii
  19. The rash appears on what day of the Rickettsia infection?
    4-6th day
  20. Sever Headach is one of the symptoms of Rickettsi infection (T/F)?
    True
  21. Typhus group of Rickettsial Diseases includes what disease?
    Epidemic Typhus
  22. Epidemic Typhus is caused by what Rickettsia
    Rickettsia prowazekii
  23. What are the symptoms of a Rickettsia prowazekki infection?
    • fever
    • severe headache
    • skin rash (trunk to extremities)
  24. Rickettsia prowazekii causes what disease?
    Epidemic typhus
  25. Epidemic Typhus is usually spread by
    body louse (bite and feces)
  26. Rickettsia prowazekii is transferred to humans via:
    body louse (bites and feces)
  27. A skin rash of Rickettsia prowazekii is on what body part?
    trunk to extremities
  28. Epidemic typhus has a rash that is located where?
    trunk to extremities
  29. The spotted fever group of Rickettsia includes:
    Rickettsia rickettsii
  30. Rickettsia rickettsii is also known as
    Rocky mountain spotted fever
  31. Rocky mountain spotted fever is transferred by
    tick bite
  32. Rickettsia rickettsii causes a rash where?
    • wrists to palms
    • trunk to ankles and soles of feet
  33. Rocky mountain spotted fever symptoms are:
    • Rash on wrists and ankles
    • fever
    • severe headache
  34. A skin rash on the writs that may extend to palms or onthe ankles and may extend to teh soles of feet and trunk is fom what Rickettsia and Disease?
    Rickettsia rickettsii, Rocky mountain stopped fever
  35. Rickettis can be stained with
    Gimenez stain
  36. Gimenez stain colors Rickettsia what?
    pink
  37. Larvae and lymphs of Rocky mountain wood tick feed on what?
    small rodents
  38. The lifecycle of a Rocky mountain wood tick is:
    2-3 years
  39. Rocky mountain wood tick is found where?
    Rocky mountain states and in southwestern Canada
  40. Adult ticks feed on what?
    large mammals
  41. Only the Rocky mountain wood tick can carry R. rickettsia (T/F)
    False, others have been shown to also carry it, but play a more minor role
  42. The Scrub typhus group includes:
    Orienta tsutsugamushi
  43. Orienta tsutsugamushi causes:
    Scrub typhus
  44. Scrub typhus is caused by:
    Orienta tsutsugamushi
  45. Orienta tsutsugamushi is transferred via:
    A mite bite
  46. The symptoms of an Orienta tsusugamushi infection are:
    • fever
    • severe headache
    • Eschar skin rash that cover body
  47. The Q fever group includes:
    Coxiella burnetii
  48. Coxiella burnetii causes:
    Q-fever
  49. Coxiella Burnetii is transferred via
    Inhaled aerosol
  50. Coxiella burnetii can resist dessication outside of host for:
    Up to 3 years
  51. Sypmtoms of Q fever are
    • intermittent fever
    • pneumonia
    • NO SKIN RASH
  52. All other diseases of Rickettsia cause a rash except:
    Coxiella burnetii's Q fever
  53. Trench fever group has been transferred to:
    Bartonella
  54. Trench fever group includes:
    Rochalimaea quintana
  55. Rochalimaea quintana causes:
    Trench fever
  56. Rochalimaea quintana is transferred via:
    body louse bite and feces
  57. Trench fever is transferred via:
    Body louse bite and feces
  58. Trench fever symptoms are:
    • fever
    • headache
    • mild symptoms
    • skin rash (global)
  59. Early stages of Rickettsia infections show a rise in serum antibodies (T/F)?
    False
  60. Diagnosis of Rickettsi infections can be performed by what three main assays?
    • MIF (microimmunoflourescence)
    • PCR
    • Cross reacting Proteus antigens
  61. MIF or Microimmunoflourescence assay detects Rickettsia by:
    detetcing antibodies directed against a specific outer membrane protein
  62. PCR is a good way to detect Rickettsia (T/F)?
    False, it is not well developed
  63. Which detection method for Rickettsia is an agglutination reaction?
    Cross-reacting Proteus antigens
  64. Which Rickettsi detetction assay uses outer membrane proteins to detect serum antibodies of Rickettsia?
    MIF or Microimmunoflourescence
  65. Which Rickettsi disease has a vaccine under study?
    Q fever
  66. Prevention fo Rickettsia can be performed by:
    Using insectisides and cleaning
  67. Q fever has a vaccine currently available?
    no but there is one being tested
  68. Pharmaceutical treatment of Rickettsia includes:
    doxycycline and chloramphenicol
  69. Chloramphenicol is the best choice drug for a Rickettsia infection (T/F)?
    False, it has a greater change of relapse
  70. Teh first line drug for Rickettsia infections is:
    Doxycycline
  71. Ehrlichia invades what types of cells?
    white cells (lymphocytes neutrophils and monocytes)
  72. Whrlickia reservoirs other than human are:
    ticks, deer and dogs
  73. ticks transfer Ehrlichia to what mammals:
    Himans, deer and dogs
  74. What percent of patient show a rash when infected with Ehrlichia?
    20%
  75. Most patients have a rash when infected with Ehrlichia (T/F)?
    False, only 20%
  76. Symptoms of Ehrlichia are:
    • Lymph node enlarged
    • high fever
    • headache
    • malaise
    • myalgia
  77. Myalgia is a symptom of Ehrlichia (T/F)?
    True
  78. Myalgia is:
    Muscle pain
  79. Ehrlichia is treatmed with:
    Doxycycline
  80. Chlamydia is related to bacteria by:
    • DNA and RNA presence
    • Binary fission division
    • G- like cell wall
    • susceptible to antibiotics
  81. Chlamydia has a cell wall much like a G - (T/F)?
    True
  82. Chlamydia divide by what process?
    Binary fission
  83. Chlamydia contain only RNA (T/F)?
    False, they contain both DNA and RNA
  84. Chlamydia is divided into how many groups?
    3
  85. The three groups of Chlamydia are:
    • Chlamydia trachomatis (group A)
    • Chlamydophila psittaci (group B)
    • Chlamydophila pneumoniae (group C)
  86. Chlaymydia group c includes:
    Chlamydophila pneumoniae
  87. Chlamydophila psittaci is in which Chlamydia group
    Group B
  88. Grou A Chlamydia includes:
    Chlamydia trachomatis
  89. The development cycle of Chlamydia is:
    • Cell engulfs Elementary body
    • Elementary body enlarges in the cell to become reticulate body
    • Cell ruptures and releases elementary bodies
  90. Trachoma is limited to what mammals?
    Humans
  91. Trachoma is found in many animals (T/F)?
    False, only humans
  92. Trachoma infects what cells?
    epithelial cells of the eye
  93. Trachoma is a Chlamydia disease in which group?
    Group A
  94. The greatest single cause of blindness is:
    Trachoma
  95. Trachoma is prominent in areas of:
    poor sanitation
  96. The onset of Trachoma is slow (T/F)
    False, it is abrupt
  97. Symptoms of Trachoma are:
    • inflammed conjunctiva
    • lymphocytes accumulate to form follicles
    • Blindness
  98. Blindnes of Trachoma is caused by:
    lymphocytes accumulating to form follicles in the eye
  99. Group A Chlamydia diseases include:
    • Trachoma
    • Inclusion conjunctivitis
    • Lymphogranuloma venereum (LGV)
    • Non-gonococcal urethritis (NGU)
    • Chlamydiosis
  100. Diagnosis of Trachoma is performed by:
    • Isolate organism form conjunctiva
    • test eye secretions for trachoma antibodies
  101. Inclusion conjunctivitis is in what Chlamydia group?
    Group A
  102. Inclusion Conjuctivitis causes disease in what two groups?
    infants and adults
  103. Inclusion Conjunctivitis causes blindness (T/F)
    False, it resolves itself in a few months
  104. How long does it take to resolve Inclusion conjunctivitis?
    a few months
  105. Inclusion conjunctivitis does not cause scarring (T/F)?
    True, there is no scarring or blindess
  106. Inclusion Conjunctivitis can cause a false positive in what other type of diagnostic test?
    PAPS smear
  107. PAPS smears can be positive die to what non-related disease?
    Inclusion Conjuncitivitis
  108. Lymphogranuloma venereum (LGV) isassociated with what behavior:
    sexual promiscuity
  109. LGV stands for:
    Lymphogranuloma venereum
  110. Symptoms of Lymphogranuloma venereum are:
    • vesicles on the genitals at 7-10 days after infection
    • vesciles soon rupture w/o scarring
    • 2-8 weeks later a regional lymph nodes swell
    • Genital skin swells
  111. At what point after Lymphgranuloma venereum infection do vesicles appear on teh skin?
    7-10 days
  112. At what point in a Lymphogranuloma venereum infection do the lymph nodes swell?
    2-8 weeks
  113. Non-gonococcal urtheritis usually causes problemes in what infection group?
    Men, women rarely have problems
  114. Non-gonococcal urethritis is caused by:
    Clamydia trachomatis
  115. Non-gonococcal urtheritis can cause what risk to newborns?
    PID and pneumonia
  116. True ot False, Non-gonococcal urtheritis is chronic?
    False, it is self limiting
  117. The most prevalent bacterial STD is:
    Chlamydiosis
  118. What percent are carriers for Chlaymydiosis in the reproductive tract?
    10%
  119. Diagnosis of Chlamydiosis is by:
    PCR or Immunoflourescent probe (culture costs time)
  120. Chlamydiosis is treated by:
    tetracyclines or arithromycin
  121. Omaha is in region what based on Chlamydia ranking?
    7
  122. Chlamydia is increasing or decreasing in percent positive tests?
    Increasing steadily from 1996 to 09
  123. Clamydia rates are higher in men than women (T/F)?
    False, men have alower rate of infection
  124. The rate of Chlamydia infections are increasing in both men and women (T/F)?
    True, though men have a lower incidence, they are increasing at the same rate
  125. Thelowest states for Chlamydia infections are:
    Idaho, Utah, Minnisota, West virginia and Vermont, Maine, Massachusets and New Hampshire
  126. The area of the highest Chlamydia infection rates are:
    Southe, Spotty midwest, New York, Arizona and Colorado and Texas, Alaska
  127. The age range of most Chlamydia infections is:
    15-24 and slightly less in the 25-29 population
  128. Group B Chlamydia diseases include:
    • Psittacosis
    • Atypical pneumonia
  129. Psittacosis resivoir is:
    Parrots (and other birds)
  130. Symptoms of Psittacosis:
    • General Debility
    • Eye and nostril
  131. Psittacosis is passed to humans via:
    • dust inhalation
    • bird haldlers
    • wild birds
  132. Atypical pneumonia caused by Chlamydia Group B has what symptoms?
    • Asymptomatic for most cases
    • Chills, fever, headache and persistant cough in some
  133. Treatment of Atypical pneumonia is by:
    tetracycline
  134. Turkey flocks tend to harbour what Chlamydia disease?
    Group B Clamydophila psittaci causing Atypical pneumonia
  135. Pneumonia from Chlamydia is caused by what group and species?
    Group C, Chlamydophila pneumoniae
  136. Taiwan Acute Respiratory Strain (TWAR) is caused by:
    Chlamydophila pneumoniae
  137. Clamydophila pneumoniae is transferred via:
    person to person contact
  138. Symptoms of Chlamydophila pneumoniae infection are:
    • Sore throat
    • hoarseness
    • cough
  139. Chlamydophila pneumoniae has a fest recovery (T/F)?
    False, it has a slow recovery
  140. Chlamydophila pneumonia infections are usually severe (T/F)?
    False, they are usually mild
  141. Diagnosis of Chlamydophila pneumoniae is by:
    Culture
  142. What are elementary bodies? 
    non-replicating infectious particle that is released when infected cells rupture
  143. What are Orientia?
    Orientia is a genus of bacteria in family Rickettsiaceae
  144. What disease is caused by Coxiella burnetii?
    Q fever
  145. What are the known rickettsial agents?
    • Rickettsia
    • Ehrlichia
    • Coxiella
    • Oreintia
    • Rochalimaea

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