MIC 541-Lecture 23
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MIC 541-Lecture 23
MIC 541 Lecture 23 Creighton Pharmacy
MIC 541-Lecture 23, Creighton Pharmacy
Treponema causes what disease?
A treponema species that causes syphilis is:
Treponema Pallidum causes:
Which Spirochete group causes relapsing fever and Lyme disease?
Which Borrelia species causes relapsing fever?
Borrelia hermsii causes what disease?
Borrelia burgdorferi causes what disease?
Lyme disease is caused by what spirochte?
Which Spirochete group causes infectious jaundice?
Leptospira interrogans causes what disease?
Infectious jaundice is caused by what spirochete?
Characteristics of Spirochetes are:
motile via axial filaments
G- (diff. to determine)
Can be detected by Dark feild microscopy
Axial filaments that are responsible for movememnt of spirochetes, the configuration is:
they wrap around the cell
Detection of spirochetes is best carried out by gram stain (T/F)?
False, dark feild microscopy is preferred
Dark feild microscopy is preferentially used to detect spirochetes (T/F)?
Dark feild microscopy, the spirochete shows up what color?
Antibody satins are what color:
An axial fibril is also known as a:
Periplastic flagella lie between ________ and __________
The cell wall and the outer envelope
Treponema palladium is transferred via ________ to cause syphilis
direct contact with lesions
90% of syphilis is contracted through what behaviour?
Sexual contact is teh most common transfer of syphilis, what is the next most common?
Symptom stages of Syphilis are:
and tertiary or late
Primary syphilis is found where?
on any cutaneousor mucous mebrane surface
Syphilis primary lesions appear and disappear at what points?
3 weeks after infection they appear and 4-12 weeks after infection they disappear
There is more than one test for syphilis available (T/F)?
False, there is only one (dark field microscopy)
What are the Characteristics of Chancres associated with Primary syphilis?
base is hard but painless
Chancres of syphilis can occur on what body parts?
Any cutaneous or mucus membrane
Secondary syphilis occurs at what period?
6 weeks to several months
symptoms of secondary syphilis are:
cutaneous and mucous membrane lesions
Secondary Syphilis is or is not contagous?
Is, there are live treponemes
The majority of Secondary Syphilis infections have what symptom?
macular skin rash
Secondary Syphilis have lesions on what body part?
Cutaneous and mucous membrane lesions
Latenet Syphilis occurs at what time period?
Early latent period = 2 years or less
Late latent period = over 2 years
During the Early latent period infectious lesions may reappear (T/F)?
During what period may infectous syphilitic lesions reappear?
During the Early latent period
During the late latent period of syphilis can be spread (T/F)?
False, this is a non-infectous stage
the syphilitic latent period ends at what time period?
May last a lifetime
Characteristics of the latent period of syphilis are:
over 2 years from infection
may continue for remainder of life
Teriary of Late stage syphilis is an infectous stage (T/F)?
Gummas are present in what stage of syphilis?
tertiary or late stage
Gummas of syphilis have these characteristics:
granulomatous found in skin SQ, deep tissue, bone (tibia = saber skin syndrome), neurosyphilis
Which sex has a greater incidence of syphilis?
Syphilis is increasing in the U.S. (T/F)?
Syphilis hit its low point in:
Syphilis is primarily found in what region?
the south and arizona
The greatest incidence of syphilis is found in what state?
Diagnosis of Syphilis is by:
Examine exudate by dark field microscopy
Serological tests for Syphilis are:
VDRL/ agglutination test for treponemal antibody
FTA (flourescent treponemal antibody)
TPHA (T. pallidum hemagglutination) = most sensitive
Treatment of syphilis is by:
primary secondary and ealry latent = benzathine penicillin (2.4 million U IM in each dose)
Tretament for late latent syphilis and tertiary syphilis is:
7.2 million U administered via 2.4 million U IM per week.
Neurosyphilis is treated by:
Aqueous crystalline penicillin 18-24 million Units a day for 10-14 days.
Dark field microscopy is used to detect what syphilitic stages?
primary, secondary and early latent
VDRL is used to diagnose what stage of syphilis?
Primary (no late)
Borrelia is detected using:
stained blood smear ot ELISA
Treatment for Borrelia is:
tetracycline and chloramphenicol
Borrelia hermsii is transferred by:
Borrelia hermsii is found in what geographical area?
Symptoms of an infection fo Borrelia hermsii are:
chills, fever, relapse (though some are asymptomatic)
Some cases of Borrelia hermsii are asymptomatic (T/F)?
Onset of symptoms for Borrelia hermsii occur at what time?
3-4 days after infection
relapse fo fever by B. hermsii is caused by:
Subsequent infections by B. hermsii with mutated antigens
Lyme disease is caused by:
Borrelia Burgdorferi is common in what state?
Resovoirs for B. burgdorferi are:
tick, deer, human and mice
Lyme disease was decreasing in incidence (T/F)?
False, the incidence continues to increase
Most reported cases of Lyme disease are in what regions?
Michigan and the atlantic coast from Maryland to Maine
Nebraska has a high incidence of Lyme disease (T/F)?
False, there are very few.
The states with the four highest incidence of Lyme disease are (in order from highest to lowest INCIDENCE):
2.) New Jersey
4.) New York
WHat type of tick transfers Lyme disease?
Black legged tick
Black legged ticks are large (T/F)?
False they are much smaller than other varieties
Larval and nymph stages of black legged ticks are approx. what size?
No bigger than a pin head
Ixodes scapularis are also know as:
black legged ticks
Black legged ticks, genus species is:
Symptoms of Lyme disease include a rash that can be described as:
Bull's eye or an erythema migrans
The adult female black legged tick is approx. how many inches wide?
2/10-3/10 of an inch
Common symptom of late disseminated Lyme disease?
Acrodermatitis chronica atrophicans - bluish red skin lesions
Blueish red skin lesions are symptomatic of what disease?
Late Lyme disease
Treatment for early Lyme disease is:
Doxycycline or amoxicillin for 3-4 weeks
Lyme disease treatment for those allergic to penicillin is:
Cefuroxime axetil or erythromycin
Later disease treatment for Lyme disease is:
IV ceftriaxone or penicillin for 4 weeks or more
Tretament is almost always successful in all stages of Lyme disease (T/F)?
False, late stage oftern fails at a rate of 10-20% and require retreatment
Leptospira interrogans is transferred via:
Leptospira interrogans causes what symptoms:
Diagnosis of Leptospira interrogans is performed by:
microscopic agglutination test
Treatment of a Leptospira interrogans infection is done with:
penicillin and tetracycline
How is Lyme disease spread?
Through black legged ticks that carry the bacteria from human and deer where they ley eggs and then the larvae migrate to rodents where they grow into adults and reinfect humans and deer.
What is a bull's eye lesion
A round lesion a round the area of a tick bite. Also known as erythema migrans
Is Lyme disease treatable?
Early stage =
doxycycline or amoxacillin for 3-4 wks
(Cefuroxime axetil or wrythromycin in those allergic to above)
Late Stage = IV ceftriaxone or penicillin for 4wks +
Treatment may fail on first try in 10-20%
What are the characteristics of tertiary syphilis?