parhm exam 3

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parhm exam 3
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2013-03-24 19:09:57
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exam 3
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  1. Levodopa (L-DOPA)
    • PARKINSONS
    • Increases DA
    • Poor bioavailability (97% metabolized in periphery)
  2. Carbidopa
    • PARKINSONS
    • Blocks levodopa conversion into DA in periphery
    • Allows levodopa to pass BBB
    • Carbidopa cannot pass BBB itself, otherwise it would breakdown levodopa there too
  3. Entacapone
    • PARKINSONS
    • COMT Inhibitor
    • Increase amount of L-DOPA available to DA neurons by decreasing metabolism in periphery
    • Useful against on/off syndrome
  4. Selegiline
    • PARKINSONS
    • MAOB selective inhibitor
  5. Rasagiline
    • PARKINSONS
    • MAOB selective inhibitor
    • May slow the progression of Parkinson's
  6. Ropinirole
    • PARKINSONS
    • Dopamine receptor agonist
  7. Haloperidol
    • SCHIZOPHRENIA
    • First generation anti-psychotic medication
    • Blocks D2-like Rs
  8. Clozapine
    • SCHIZOPHRENIA
    • Blocks serotonin and D2-like Rs
    • Most effective antipsychotic available
  9. Olanzapine
    • SCHIZOPHRENIA
    • 2nd generation anti-psychotic
    • Designed to target Serotonin Rs
    • Also blocks D2-like DA Rs
  10. Quetiapine
    • SCHIZOPHRENIA
    • 2nd generation anti-psychotic
    • Designed to target Serotonin Rs
    • Also blocks D2-like DA Rs
  11. Nicotine Replacement
    • TOBACCO USE
    • Not very effective
  12. Varenicline
    • TOBACCO USE
    • Nicotinic receptor partial agonist
    • Longer, sustained increase of DA
  13. Bupropion
    • TOBACCO USE
    • Inhibits the uptake of monoamines
    • Stabilize dopamine levels following tobacco withdrawal
  14. Methadone
    • OPIATE ABUSE
    • Mu opioid R agonist
    • Preventing withdrawal
    • Transfer dependence/addiction to methadone
  15. Clonidine
    • OPIATE ABUSE
    • Decrease activity by stimulating a2 receptor (autoreceptor)
    • Inhibit release of ACh
    • Decrease the severity of withdrawal by decreasing ACh
  16. Naltrexone
    • OPIATE ABUSE
    • Opioid antagonist
    • Generate rapid and severe withdrawal state
    • Anesthesia usually administered too
  17. Buprenorphine
    • OPIATE ABUSE
    • Partial agonist
    • Promotes tolerance
    • Prevents rapid on-off activation of reward mediator
    • Harder to reach a high/euphoria
  18. Diazepam
    • ALCOHOL ABUSE
    • Depresses CNS activity
    • Long-acting sedative
  19. Carbamazepine
    • ALCOHOL ABUSE
    • Depresses CNS activity
  20. Disulfiram
    • ALCOHOL ABUSE
    • Blocks acetaldehyde dehydrogenase
    • Results in flushing, nausea, headache, dysphoria
  21. Naltrexone
    • ALCOHOL ABUSE
    • Opioid receptor antagonist
    • Blocks endogenous reward system
  22. Acamprosate
    • ALCOHOL ABUSE
    • Blocks glutamate receptors
    • Reduces craving, doesn't prevent withdrawal
  23. Triazolam
    • ANXIETY
    • Benzodiazepine
  24. Alprazolam
    • ANXIETY
    • Benzodiazepine
  25. Diazepam
    • ANXIETY
    • Benzodiazepine
  26. Flumazenil
    • ANXIETY
    • Benzodiazepine antagonist
  27. Phenobarbital
    • ANXIETY
    • Barbituate
  28. Pentobarbital
    • ANXIETY
    • Barbituate
  29. Zolpidem
    • ANXIETY
    • Exhibit affinity for a1 containing GABAA Rs
    • Increases sleep time
    • Short half life
    • More restricted than BZD
  30. Zaleplon
    • ANXIETY
    • Exhibit affinity for a1 containing GABAA Rs
    • Increases sleep time
    • Short half life
    • More restricted than BZD
  31. Buspirone
    • ANXIETY
    • Serotonin Partial Agonist
    • Decreases firing rate of 5-HT neurons
    • Used to treat situational anxiety, generalized
  32. Venlafaxine
    • ANXIETY
    • SNRI
  33. Clonidine
    • ANXIETY
    • a2 receptor agonist
    • Stimulating an autoreceptor
    • Suppresses Sympathetic NS
  34. Propanolol
    • ANXIETY
    • Beta (B1¬†& B2)¬†receptor antagonist
    • Reduces Sympathetic NS activity
    • ****Drug that interacts with benzos
  35. Alcohol
    ****Drug that interacts with benzos
  36. Fluoxetine
    ****Drug that interacts with benzos
  37. Fluvoxamine
    ****Drug that interacts with benzos
  38. Paroxetine
    ****Drug that interacts with benzos
  39. Phenylephrine
    a1 receptor selective AGONIST
  40. Prazosin
    a1 receptor selective ANTAGONIST
  41. Terazosin
    a1 receptor selective ANTAGONIST
  42. Tamsulosin
    a1 receptor selective ANTAGONIST
  43. Dobutamine
    B1 receptor selective AGONIST
  44. Albuterol
    B2 receptor selective AGONIST
  45. Atenolol
    • B1 receptor selective ANTAGONIST
    • cardioselective
  46. Acebutolol
    B1 receptor selective partial agonist (has ISA)
  47. Pilocarpine
    • CHOLINERGIC DIRECT ACTING
    • Muscarinic receptor agonist
  48. Bethanechol
    • CHOLINERGIC DIRECT ACTING
    • Muscarinic receptor agonist
  49. Atropine
    • CHOLINERGIC DIRECT ACTING
    • Muscarinic receptor antagonist (antimuscarinic)
  50. Scopolamine
    • CHOLINERGIC DIRECT ACTING
    • Muscarinic receptor antagonist (antimuscarinic)
  51. Ipratropium
    • CHOLINERGIC DIRECT ACTING
    • Muscarinic receptor antagonist (antimuscarinic)
  52. Tolterodine
    • CHOLINERGIC DIRECT ACTING
    • Muscarinic receptor antagonist (antimuscarinic)
  53. Physostigmine
    • CHOLINERGIC INDIRECT ACTING
    • Anticholinesterase (Reversible)
  54. Organophosphates
    • CHOLINERGIC INDIRECT ACTING
    • Anticholinesterase (Irreversible)
  55. Botox
    • CHOLINERGIC INDIRECT ACTING
    • Acetylcholine Release Inhibitor

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