Is Cushing Syndrome a result of hypo or hyper function?
Hyperfunction of adrenal cortex, so you get hypercortisolism
What is the difference between Cushing Syndrome and Disease?
Syndrome: chronic hyperfunction of adrenal cortex
Disease: too much ACTH from pituitary
--Primary: problem with adrenal gland
--Secondary: pituitary adenoma
How will a patient with Cushing Syndrome present?
Weight gain with abnormal distribution, abdominal striae, glucose intolerance (>>DM), protein wasting, osteoporosis, hypercalciuria, loss of collagen, HTN, mood disturbances, impaired inflammation and immune responses, poor wound healing, gastric bleeding
How does adrenal medulla hyperfunction manifest?
Because the medulla secretes catecholamines, you may see very high BP
How does adrenal medulla hypofunction manifest?
It doesn't really. Other organs will take over to secrete catecholamines.
What is the role of calcitonin?
Decreases serum calcium by inhibiting osteoclastic activity and increase osteoblastic activity