MODA DRUGS (7)

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Author:
yl456
ID:
209692
Filename:
MODA DRUGS (7)
Updated:
2013-03-27 08:32:46
Tags:
Inflammation
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moda
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  1. Alemtuzumab
    • CD25 target
    • binds to B cells and so marks them for destruction via cell-based immunity.
    • Used in B-cell CLL, multiple sclerosis
  2. Aspirin
    • Non-selective COX inhibitor
    • Anti thrombotic at low doses
    • irreversible inactivation
    • side effects: salicylate poisoning, Reye’s syndrome, hypersensitivity reactions
  3. Azathioprine
    • inhibitor of immune cell proliferation
    • inhibit synthesis of guanosine and therefore inhibit DNA synthesis
  4. Celecoxib
    COX-2 selective NSAID
  5. Cimetidine
    • H2 selective antagonist
    • Treats gastric ulceration- reduces acid secretion
  6. Clarithromycin
    Antibiotic eradication of Helicobacter pylori
  7. Cyclosporin
    • calcineurin inhibitor which inhibit T-cell proliferation
    • Inhibits secretion of IL2
  8. Dexamethasone
    long acting corticosteroid
  9. Dimenhydrinate
    • CNS-penetrant antihistamine
    • Treats motion sickness
    • H1 antagonists
  10. Ibuprofen
    • NSAID
    • reversible and competes with arachidonic acid for binding within COX enzymes
    • Non-selective between COX1 and COX2
  11. Infliximab
    • Bind TNFα
    • used to treat rheumatoid arthritis, crohn's disease
  12. Ipratropium
    • Muscarinic antagonist
    • Against asthma and COPD
  13. Loratidine
    • Antihistamine, H1 receptor
    • Third generation antagonist
  14. Methotrexate
    • Rheumatoid arthritis
    • antiproliferative drug used in cancer chemotherapy
    • inhibits folate biosynthesis and DNA duplication by reducing availability of thymidine
  15. Metoclopramide
    • Anti-emetic drug used in the treatment of chemotherapy-induced nausea
    • D2 antagonist
  16. Mycophenolate
    • Inhibits guanosine synthesis and so prevents B, T cell proliferation
    • Transplantation and immunosuppression
  17. Omalizumab
    • Binds IgE
    • Used in asthma
  18. Omeprazole
    • Proton pump inhibitor (reduces gastric acid secretion)
    • Treat gastric ulcers
  19. Ondansetron
    5HT3 antagonist used as anti-emetic
  20. Paracetamol
    • NSAID
    • Non-selective COX inhibitor. Little anti-inflammatory action
  21. Prednisolone
    Short-acting corticosteroid
  22. Ranitidine
    • H2 receptor antagonist – reduces gastric acid secretion
    • Treat gastric ulcers
  23. Scopolamine
    Muscarinic antagonist used as anti-emetic
  24. Sirolimus
    • Inhibits mTOR - blocks late activation of T and B cells
    • Transplantation and immunosuppression
  25. Sulfasalazine
    • used to treat rheumatoid arthritis
    • Interferes with lymphocytes
  26. Sumatriptan
    Class of 5HT1D agonists used to control migraine
  27. Tacrolimus
    • Calcineurin inhibitors. Inhibit secretion of IL2
    • Transplantation and immunosuppression
  28. Zafirlukast
    • Leukotriene D4 and E4 receptor antagonist
    • used to treat asthma and COPD
  29. Zileuton
    • Inhibitor of 5-lipoxygenase (inhibits production of leukotrienes)
    • used to treat asthma and COPD

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