MODA DRUGS (8)

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Author:
yl456
ID:
209813
Filename:
MODA DRUGS (8)
Updated:
2013-03-27 10:02:11
Tags:
Vet Pharmacology
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Description:
moda
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  1. Adrenaline
    • Adrenergic agonist
    • α2 >=α1 >β1 =β2
  2. Noradrenaline
    • Adrenergic agonist
    • a1 > a2 = b1 >> b2
  3. Phenylbutazone
    • Vet NSAID
    • Scavenges free radicals
    • eliminated principally by drug metabolism
  4. Flunixin
    • Vet NSAID
    • Anti-bradykinin effects
    • Inhibition of NFkB
  5. Carprofen
    • Vet NSAID
    • Inhibition of cytokine release
    • Inhibition of NFkB
    • Human: COX-1 > COX-2
    • Horse: COX-1 = COX-2
    • Dog/Cat: COX-1 < COX-2
  6. Loperamide
    kept out of the brain by P-glycoprotein
  7. Coumarin
    • Analogue= warfarin, 4-hydroxycoumarin, Dicoumarol
    • Anti-coagulant rodenticide
  8. Etamiphylline
    • Methylxanthines
    • Commonly used cardiac & respiratory stimulant in veterinary practice
  9. N-acetyl cysteine
    Replenishes GSH in acute liver failure
  10. Purine
    Includes: xanthine, theobromine, uric acid and caffeine
  11. Theobromine
    • Purine
    • Methylxanthine
    • Toxic to dogs (some cats)
    • In chocolate
  12. Theophylline
    • Methylxanthines
    • Bronchodilator/respiratory stimulant
  13. Xanthine
    • Uric acid is metabolite
    • Methylxanthines: anatagonists of adenosine receptors, inhibitors of phosphodiesterase, activation of ryanodine receptors [positive ionotropic effect]

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