Clinical PET STUDIES

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Author:
asparkle23
ID:
209938
Filename:
Clinical PET STUDIES
Updated:
2013-03-27 22:14:32
Tags:
Kowalski Pharmacy
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Description:
PET STUDIES
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  1. What are some CARDIAC PET tracers?
    • PERFUSION:
    • Ammonia
    • Rb
    • Flupiridaz

    • METABOLISM:
    • F-18 FDG
  2. What are 2 properties in cancer cells?
    • 1.^Glucose and hexokinase levels
    • 2. ^ Amino acid transport and protein synthesis
  3. How is FDG used?
    • 1. Detection
    • 2. Staging
    • 3. Response and recurrence
  4. Why is FDG not used as a cardiac perfusion agent?
    Heart uses fatty acids not glucose
  5. What are the risk classifications for melanoma?
    • <1mm= LOW
    • 1-3mm= node mets 20-50%
    • >3= node mets 50-70%
  6. What are some other F-18 agents besides FDG?
    • Sodium Flouride (Bone Mets)
    • Fluorodopa (Parkinson's)
    • Fluorothymidine [FLT] (Breast CA etc)
    • C-11 Choline (Prostate)
  7. Why do peds get more dose for bone imaging?
    B/c peds are constantly creating new bones=^uptake=^dose
  8. Why is hypoxia imaging important?
    Cells closer to blood supply have more O2; more hypoxic=more resistant to chemo=more tumor growth
  9. Describe F-18 Miso in hypoxia imaging
    • Oxic Cells: Miso is reoxidized and diffuses out of cells
    •  
    • Hypoxic Cells: Miso remains reduced and trapped

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