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dunks406
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Class
Cholinesterase Reactivator , (2 PAM)
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Pharmacology and Actions
Reactivates the cholinesterase inhibited by phosphate esters by displacing the enzyme from its receptor sites. This restores the normal functions of the neuromuscular transmission.
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Indications
An antidote and treatment for organophosphate poisoning
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Contraindications
- Severe Cardiac Disease
- Peptic Ulcer
- Asthma
- MI
- Hypersensitivity to Procainamide / Procaine
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Precautions and Side Effects
- Tachycardia
- Hypertension
- Dizziness
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Dosage (Adult)
1-2 grams in 250-500ml of NS infused over 15-30 mins ; if no IV access is available 1-2 grams IM / SC
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