Monocytes and Macrophages

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Monocytes and Macrophages
2013-05-18 23:44:17
Review Maturation Morphology Characteristics Function Nonmalignant Disorders

Review, Maturation, Morphology, Characteristics, Function, Nonmalignant Disorders
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  1. What macrophages are located in the liver?
    Kupffer cells
  2. What macrophages are located in the CNS?
    Microglial cells
  3. What macrophages are located in the bone?
  4. What macrophages are located in the skin?
    Langerhans' cells
  5. What macrophages are located in the lung?
    Alveolar cells
  6. Describe a monoblast
    • 1-2 nucleoli
    • Dark blue cytoplasm
    • May have gray tint
    • No cytoplasmic granules
  7. Describe a promonocyte
    • 0-1 nucleoli
    • Blue to gray cytoplasm
    • Fine azurophilic granules
  8. Describe a monocyte
    • Horseshoe or kidney bean shaped nucleus
    • Fine, lacy chromatin
    • Blue-gray cytoplasm
    • May have pseudopods and vacuoles
    • Many fine azurophilic granules give the appearance of "ground glass"
  9. Describe a macrophage
    • Blue-gray cytoplasm with many vacuoles
    • Coarse azurophilic granules may contain ingested material
  10. What is the reference range of Monocytes in peripheral blood?
  11. What is the function of monocytes/macrophages?
    • Major role in initiating and regulating the immune response
    • Process ingested material
    • Process antigenic information, which is relayed to the T-helper (CD4) lymphocyte
    • Very efficient phagocytic cells with receptors for IgG or complement-coated organisms
    • Secrete cytokines/interleukins and tumor necrosis factor
  12. What cells are known as "scavenger cells"?
    • Monocyte/Macrophage
    • Because of their ability to ingest foreign material
  13. What do blood monocytes ingest?
    • Antigen-antibody complexes
    • Activated clotting factors
    • Limiting the coagulation response
  14. What do splenic macrophages ingest?
    • Old/damaged RBCs
    • Conserve iron for recycling
  15. What do liver macrophages ingest?
    Fibrin degradation products
  16. What do bone marrow macrophages ingest?
    • Abnormal RBCs
    • Ingest bare megakaryocyte nuclei or extruded RBC nuclei
    • Store and supply iron for hemoglobin synthesis
  17. What is associated with monocytosis?
    • Recovery stage from acute bacterial infections
    • Recovery following marrow suppression by drugs
    • Tuberculosis
    • Syphilis
    • Subacute bacterial endocarditis
    • Autoimmune disorders (systemic lupus erythematosis, rheumatoid arthritis)

  18. What condition:
    Is the most common lipid storage disorder 
    Has an autosomal recessive inheritance pattern
    Deficiency in glucocerbosidase
    Glucocerboside accumulates in macrophages of the bone marrow, spleen, liver, with this cell more commonly seen in the bone marrow
    • Gaucher disease
    • (Gaucher cell looks like crumpled paper)

  19. What condition:
    Disease has an autosomal recessive inheritance pattern 
    Deficiency in sphingomyelinase
    Sphingomyelin to accumulate in macrophages in multiple organs and bone marrow, where this cell can be seen
    • Niemann-Pick disease
    • (Niemann-Pick foam cell)
  20. What is associated with monocytopenia?
    Aplastic anemia