Class: Antiarrhytmic (class 3)
Action: Prolongs action of potential and refactory period. Slows the sinus rate, increases PR and QT intervals, Decreases peripheral vascular resistance (a and b adrenergic blockade)
Inducations: Life threating cardiac arrhythmias such as V-tac and V-fib
contrainducations: Severe sinus node dysfunction, Sinus bradycardia, Second and thrid-degree atrioventricular block, Hemodynamically significant bradycardia
Precautions: Heart failure
Side effects: Hypotension, nausea, Anorexia, Malaise(fatigue), Tremors, Pulmonary toxicity, ventricular ectopic beats.
- Dosage: v-Fib or Pulseless V-Tach Adults 300mg may be repeated @ 150mg for recurrent or refactory arrhythmias.
- Narrow-complex tachycardias- dosed @ 150mg IV/IO over 10 minute and repeated as necessary. this can be followed by a 1mg/min infustion over 6 hours, followed by a .5mg/min infustion as needed. total 24 hour dose should not exceed 2.2gm
Pediatric dosage: 5mg/kg IV/IO over 30 minutes. May be repeated twice up to 15/kg max single dose 300mg