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Where is phosphate found?
55% free ion
12% protein bound
How is Phos eliminated from our bodies?
freely filtered a the glomerulus
What are some important role of phosphate in our bodies?
It is the high energy bond of ATP
used in the cell membranes
serves as a urinary buffer
How doe we treat hypophos?
What is occurring when the phos level is low?
cellular energy deficiency
low levels of 2-3DGP (O2 bound tighter)
How does phos help release oxygen from hgb?
It is part of 2-3 DPG
At what level to we see severe organ dysfunction?
Why are pt's with low levels of phos prone to infection?
phos contributes to WBC's ability to fight infection.
Is rhabdo a possible complication of hypophos?
What type of pt's is hypophos common in?
What causes hypophos?
shift of phos into ICF
Increased loss thought kidneys
decreased absorption from GI
Why do we want to replace phos carefully?
increased phos levels can precipitate a fall in Ca
Are the symptoms of hyperphos related to the phos level or low Ca level associated with hyperphos?
Low Ca levels
How does hyperphos occur?
rapid lysis of cells:
renal failure is the most common cause
Excretion of phos fails when the GFR is
How do we treat hyperphos?
treat the underlying cause
correcting any associated hypoCa
restrict intake and increase excretion
What medications might we use to increase excretion of phos?
BC Boston College chem phos
BC Boston College chem: phos