What are the medical options for treatment of recurrent respiratory papillomatosis?
Interferon use is much less common today, though it’s effective. The decrease in use is due to the side effects associated with the drug and the success of intralesional cidofovir. The acute side effects are fever and generalized flu-like symptoms as well as nausea and vomiting. They tend to subside with prolonged therapy. Chronically, interferon can cause growth rate decreases in children, elevated liver enzymes, alteration in the central nervous system (leukopenia spastic diplegia) and febrile seizures, as well as thrombocytopenia. There is a statistically significant difference in responses based upon HPV subtype, with 68% of patients with HPV 6 remaining in remission at the end of the follow-up in contrast to only 18% of patients with HPV 18.