Pharm Final: DM (Instructor specific questions)

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choward04
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211706
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Pharm Final: DM (Instructor specific questions)
Updated:
2013-04-06 08:20:13
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Pharm
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Pharm
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  1. Which DM drug has increased risk for lactic acidosis if renal impairment is present?
    Metformin
  2. Unless contraindicated, all T2DM should be treated with which DM drug upon diagnosis?
    Metformin
  3. Which drug that produces hypoglycemia should NOT be treated with orange juice?
    Alpha-Glucosidase Inhibitors (can use milk, glucose tab)
  4. Which pancreatic cells produce glucagon?
    Alpha cells
  5. Which pancreatic cell produces insulin?
    Beta cells
  6. What peptide hormone is co-secreted with insulin from Beta cells in RESPONSE TO FOOD?
    Amylin (inhibits glucagon secretion, delays gastric emptying, satiety agent
  7. Which insulin should NOT be used in pregnant women?
    Lantus
  8. Impairment of ischemic preconditioning increasing cardiac mortality is a concern for what DM drug?
    Sulfaureas (b/c heart channels)
  9. Which medication is a PPAR selective agonist and takes a long time to be effective?
    • TZDs (PPAR--> increase GLUT-4 transporter production,)
    • -->insulin must be present to be effective
    • --> Actos (Pioglitazone) & Avandia
  10. Which medication and assist 1st phase insulin secretion and supresses glucagon at the same time, targeting post meal rise?
    GLP-1
  11. Which has a Black Box Warning for hypoglycemia unawareness?
    Symlin, especially in Type 1
  12. Which analog basal insulin is adminestered once daily?
    Lantus
  13. Which insulin has a rapid onset, 15min?
    Any analog insulin (Humalog, Novolog, Apidra)
  14. Which insulin is short acting, onset 30-60min. Has to be taken 45min before eating?
    Regular

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